方面 工作 的知 识和 能 力。 三、教学内容 第一章Introduction to Biopharmaceutics and Pharmacokinetics 1.教学目标 (1)Understanding the definition of biopharmaceutics and pharmcokinetics,and relationship with drug product performance. (2)Describe the role of biopharmaceutics and pharmcokinetics in a new drug development and clinical application. 2.教学重难点 (1)The definition of biopharmaceutics and pharmacokinetics. (2)The application of biopharmaceutics and pharmacokinetics in new drug development and clinical drug application. 3.教学内容 Drug Product Performance,Biopharmaceutics,Pharmacokinetics,Pharmacodynamics,Clinical Pharmacokinetics,Measurement of Drug Concentrations,Basic Pharmacokinetics and Pharmacokinetic Models
方面 工作 的知 识和 能 力。 三、教学内容 第一章 Introduction to Biopharmaceutics and Pharmacokinetics 1.教学目标 (1) Understanding the definition of biopharmaceutics and pharmcokinetics, and relationship with drug product performance. (2) Describe the role of biopharmaceutics and pharmcokinetics in a new drug development and clinical application. 2.教学重难点 (1) The definition of biopharmaceutics and pharmacokinetics. (2) The application of biopharmaceutics and pharmacokinetics in new drug development and clinical drug application. 3.教学内容 Drug Product Performance, Biopharmaceutics, Pharmacokinetics, Pharmacodynamics, Clinical Pharmacokinetics, Measurement of Drug Concentrations, Basic Pharmacokinetics and Pharmacokinetic Models
4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom will be encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第二章Mathematical Fundamentals in Pharmacokinetics 1.教学目标 (1)Learn to algebraically solve mathematicalexpressions related topharmacokinetics. (2)Express the calculated andtheoretical pharmacokineticvalues in proper units. (3)Define various modelsrepresenting rates and orderof reactions and calculatepharmacokinetic parameters(eg,zero-and first-order)fromexperimental data based onthese models. 2.教学重难点 (1)Mathematicalexpressions related topharmacokinetics (2)Rates and orderof reactions and calculatepharmacokinetic parameters(eg,zero-and first-order) fromexperimental data 3.教学内容 Calculus,Graphs,Mathematical Expressions and Units,Units for Expressing Blood Concentrations, Measurement and Use of Significant Figures,Rates and Orders of Processes. 4.教学方法
4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom will be encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions. 第二章 Mathematical Fundamentals in Pharmacokinetics 1.教学目标 (1) Learn to algebraically solve mathematicalexpressions related topharmacokinetics. (2) Express the calculated andtheoretical pharmacokineticvalues in proper units. (3) Define various modelsrepresenting rates and orderof reactions and calculatepharmacokinetic parameters(eg, zero- and first-order) fromexperimental data based onthese models. 2.教学重难点 (1) Mathematicalexpressions related topharmacokinetics (2) Rates and orderof reactions and calculatepharmacokinetic parameters(eg, zero- and first-order) fromexperimental data 3.教学内容 Calculus, Graphs, Mathematical Expressions and Units, Units for Expressing Blood Concentrations, Measurement and Use of Significant Figures, Rates and Orders of Processes. 4.教学方法
(1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第三章0ne-Compartment0 pen Model:Intravenous Bolus Administration 1.教学目标 (1)Describe a one-compartmentmodel,IV bolus injection. (2)Provide the pharmacokineticterms that describe a onecompartment model,IV bolusinjection,and the underlyingassumptions. (3)Explain how drugs follow onecompartment kinetics usingdrug examples that follow onecompartment kinetics. (4)Calculate pharmacokineticparameters from drugconcentration-time data using aone-compartment model. (5)Calculate the IV bolus doseof a drug using the onecompartment model equation. 2.教学重难点 (1)The definition of pharmacokinetic compartment model,the significance of one compartment model for intravenous bolus administration. (2)The calculation of pharmacokinetic parameters. 3.教学内容 Elimination rate constant,apparent volume of distribution,clearance,clinical application,calculation of k from urinary excretion data
(1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions. 第三章 One-Compartment Open Model: Intravenous Bolus Administration 1.教学目标 (1) Describe a one-compartmentmodel, IV bolus injection. (2) Provide the pharmacokineticterms that describe a onecompartment model, IV bolusinjection, and the underlyingassumptions. (3) Explain how drugs follow onecompartment kinetics usingdrug examples that follow onecompartment kinetics. (4) Calculate pharmacokineticparameters from drugconcentration–time data using aone-compartment model. (5) Calculate the IV bolus doseof a drug using the onecompartment model equation. 2.教学重难点 (1) The definition of pharmacokinetic compartment model,the significance of one compartment model for intravenous bolus administration. (2) The calculation of pharmacokinetic parameters. 3.教学内容 Elimination rate constant, apparent volume of distribution, clearance, clinical application, calculation of k from urinary excretion data
4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第四章Multicompartment Models:Intravenous Bolus Administration 1.教学目标 (1)Define the pharmacokineticterms used in a two-and threecompartment model. (2)Explain using examples whydrugs follow one-compartment,two-compartment,or threecompartment kinetics. (3)Use equations and graphto simulate plasma drugconcentration at varioustime periods after an IV bolusinjection of a drug that followsthe pharmacokinetics of a twoand three-compartment modeldrug. (4)Estimate two-compartmentmodel parameters by using themethod of residuals. 2.教学重难点 Whydrugs follow one-compartment,two-compartment,or threecompartment kinetics,estimate two- compartmentmodel parameters by using themethod of residuals. 3.教学内容 Two-Compartment Open Model,Clinical Application,Three-Compartment Open Model,Determination of Compartment Models,Practical Problem 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples
4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions an d frequently asked questions. 第四章 Multicompartment Models: Intravenous Bolus Administration 1.教学目标 (1) Define the pharmacokineticterms used in a two- and threecompartment model. (2) Explain using examples whydrugs follow one-compartment,two-compartment, or threecompartment kinetics. (3) Use equations and graphto simulate plasma drugconcentration at varioustime periods after an IV bolusinjection of a drug that followsthe pharmacokinetics of a twoand three-compartment modeldrug. (4) Estimate two-compartmentmodel parameters by using themethod of residuals. 2.教学重难点 Whydrugs follow one-compartment,two-compartment, or threecompartment kinetics, estimate twocompartmentmodel parameters by using themethod of residuals. 3.教学内容 Two-Compartment Open Model, Clinical Application, Three-Compartment Open Model, Determination of Compartment Models, Practical Problem 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples
(2)Discussion method:Flipped classroom was encouraged. 5.教学评价 Take quick summary test,discuss with selected learning questions and frequently asked questions. 第五章I ntravenous Infusion 1.教学目标 (1)Describe the concept of steadystate and how it relates tocontinuous dosing. (2) Determine optimum dosing foran infused drug by calculatingpharmacokinetic parametersfrom clinical data. (3) Calculate loading doses tobe used with an intravenousinfusion. (4) Describe the purpose of aloading dose. 2.教学重难点 Pharmacokinetic parameters for one-compartment model drugs after intravenous infusion,loading dose,estimation of drug clearance and Vo. 3.教学内容 One-compartment model drugs,infusion method for calculating patient elimination half-life,loading dose plus iv infusion-one-compartment model,estimation of drug clearance and Vo from infusion data. 4.教学方法 (1)Teaching method:Relevant concepts and theoretical framework,combined with typical drug examples. (2)Discussion method:Flipped classroom was encouraged. 5.教学评价
(2) Discussion method: Flipped classroom was encouraged. 5.教学评价 Take quick summary test, discuss with selected learning questions and frequently asked questions. 第五章 Intravenous Infusion 1.教学目标 (1) Describe the concept of steadystate and how it relates tocontinuous dosing. (2) Determine optimum dosing foran infused drug by calculatingpharmacokinetic parametersfrom clinical data. (3) Calculate loading doses tobe used with an intravenousinfusion. (4) Describe the purpose of aloading dose. 2.教学重难点 Pharmacokinetic parameters for one-compartment model drugs after intravenous infusion, loading dose,estimation of drug clearance and VD. 3.教学内容 One-compartment model drugs, infusion method for calculating patient elimination half-life,loading dose plus iv infusion-one-compartment model,estimation of drug clearance and VD from infusion data. 4.教学方法 (1) Teaching method: Relevant concepts and theoretical framework, combined with typical drug examples. (2) Discussion method: Flipped classroom was encouraged. 5.教学评价