3. High Biological Efficiency Low plasma concentration(nmol-pmoL)→→ reat regulatory function
16 3. High Biological Efficiency Low plasma concentration (nmol – pmol/L) great regulatory function
I molecule at seNior acot吧n each activated recoptor protein Signal activates many molecules of G protein, ech of which in tum activate an adenylate erle FICATION activated molecule adenylate cyclase amplification during the each atate ads transmembrane mn体mm AMPLIFICATION c ch eAMP. and stives I molocule of protein kinD intracellular LIFICATION transmission wherry stemmer OOoOOoOoo 8。。。《然 each copy of rhyme x produee AMPLIFICATION ecut of prod 需:, ∴
17 Signal amplification during the transmembrane and intracellular transmission
4 Interaction between the hormones (1) Synergistic effects Additive Same effect of the hormones on one target organ for example epinephrine and norepinephrine on the heart rate Complementary: Work on different stages of a physiological procedure FSH (initiation) and testosterone (maintenance)on spermatogenesis
18 4. Interaction Between the Hormones (1) Synergistic effects. Additive: Same effect of the hormones on one target organ, for example, epinephrine and norepinephrine on the heart rate Complementary: Work on different stages of a physiological procedure, FSH (initiation) and testosterone (maintenance) on spermatogenesis
250 200 Glucagon Epinephrine Cortisol Eo9 oQ 150 Glucagon Epinephrine Epinephrine 100 Glucagon Cortisol 0 23 5 Time in hours
19
(2)Permissive effect a hormone enhances the responsiveness of a target organ to the second hormone increases the activity of the second hormone Estrogen -Expression of progesterone receptors on uterus-progesterone effect on the uterus Glucocorticoids -effects of catecholamines on cardiovascular system
20 (2) Permissive effect. A hormone enhances the responsiveness of a target organ to the second hormone increases the activity of the second hormone. Estrogen – Expression of progesterone receptors on uterus – progesterone effect on the uterus. Glucocorticoids – effects of catecholamines on cardiovascular system