课程名称 Biopharmaceutics and Pharmacokinetics 所属学科 药学 教材名称 《Applied Biopharmaceutics&Pharmacokinetics》第7版 授课年级 第六学期 授课章节 4.Multicompartment Models:Intravenous Bolus Administration 授课时间 100分钟 一、教学目标：含知识目标、技能（能力）目标 1.知识目标： (1)Define the pharmacokinetic terms used in a two-and three compartment model. (2)Explain using examples why drugs follow one-compartment,two-compartment,or three compartment kinetics. (3)Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two and three-compartment model drug. (4)Estimate two-compartment model parameters by using the method of residuals. 2.技能（能力）目标： (1)Learn basic English terms in Multicompartment models (2)Improve the skills in listening and speaking English in pharmacokinetics 二、授课内容（依据教学大纲）及时间分配 Lecture I II: Two-Compartment Open Model,Clinical Application-90 min Three-Compartment Open Model,Determination of Compartment Models,Practical Problem-10 min
课程名称 Biopharmaceutics and Pharmacokinetics 所属学科 药学 教材名称 《Applied Biopharmaceutics & Pharmacokinetics》第 7 版 授课年级 第六学期 授课章节 4.Multicompartment Models: Intravenous Bolus Administration 授课时间 100 分钟 一、教学目标：含知识目标、技能（能力）目标 1．知识目标： (1) Define the pharmacokinetic terms used in a two- and three compartment model. (2) Explain using examples why drugs follow one-compartment, two-compartment, or three compartment kinetics. (3) Use equations and graph to simulate plasma drug concentration at various time periods after an IV bolus injection of a drug that follows the pharmacokinetics of a two and three -compartment model drug. (4) Estimate two-compartment model parameters by using the method of residuals. 2.技能（能力）目标： (1) Learn basic English terms in Multicompartment models (2) Improve the skills in listening and speaking English in pharmacokinetics 二、授课内容（依据教学大纲）及时间分配 Lecture I & II: Two-Compartment Open Model, Clinical Application—90 min Three-Compartment Open Model, Determination of Compartment Models, Practical Problem —10 min
三、敦学盒点与难点 教学重难点 Why drugs follow one-compartment,two-compartment,or three compartment kinetics,estimate two-compartment model parameters by using the method of residuals. 四、教学方法选择 1.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） (1)Use case study to explain the principles and applications of Two-Compartment Open Model (2)Review the major concepts and materials covering the chapters. (3)Work on problems with students together to emphasize the basic principles covered in the chapters (4)Test could push students usually. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1)Ask questions during case studies before and after introducing basic concepts (2)Discuss the complicated concepts (3)Solve problems together with students 2.实验课教学 No applicable
三、教学重点与难点 教学重难点 Why drugs follow one-compartment, two-compartment, or three compartment kinetics, estimate two -compartment model parameters by using the method of residuals. 四、教学方法选择 1.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） (1) Use case study to explain the principles and applications of Two -Compartment Open Model (2) Review the major concepts and materials covering the chapters. (3) Work on problems with students together to emphasize the basic principles covered in the chapters (4) Test could push students usually. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1) Ask questions during case studies before and after introducing basic concep ts (2) Discuss the complicated concepts (3) Solve problems together with students 2.实验课教学 No applicable
五、更新或补充内容提要 课后总结：按照实际进度对知识点分详略进行讲解 Emphasize the key concept and adjust the amount of materials in each section 六、复习思考题 The second learning question in chapter 4. 苏州大学医学部药学院授课教案 授课教师：阮建清 授课日期：2021年4月8日 课程名称 Biopharmaceutics and Pharmacokinetics 所属学科 药学 教材名称 《Applied Biopharmaceutics&Pharmacokinetics》第7版 授课年级 第六学期
五、更新或补充内容提要 课后总结：按照实际进度对知识点分详略进行讲解 Emphasize the key concept and adjust the amount of materials in each section 六、复习思考题 The second learning question in chapter 4. 苏州大学医学部药学院授课教案 授课教师：阮建清 授课日期：2021 年 4 月 8 日 课程名称 Biopharmaceutics and Pharmacokinetics 所属学科 药学 教材名称 《Applied Biopharmaceutics & Pharmacokinetics》第 7 版 授课年级 第六学期
授课章节 5.Intravenous Infusion 授课时间 100分钟 一、教学目标：含知识目标、技能（能力）目标 1.知识目标： (1)Describe the concept of steady state and how it relates to continuous dosing. (2)Determine optimum dosing for an infused drug by calculating pharmacokinetic parameters from clinical data. (3)Calculate loading doses to be used with an intravenous infusion. (4)Describe the purpose of a loading dose. 2.技能（能力）目标： (1)Be able to calculate pharmacokinetic parameters from clinical data. (2)Improve the skills in listening and speaking English in pharmacokinetics 二、授课内容（依据教学大纲）及时间分配 Lecture I II: One-compartment model drugs,infusion method for calculating patient elimination half-life,loading dose plus iv infusion-one- compartment model,estimation of drug clearance and VD from infusion data-100 min 三、教学重点与难点 教学重难点
授课章节 5.Intravenous Infusion 授课时间 100 分钟 一、教学目标：含知识目标、技能（能力）目标 1．知识目标： (1) Describe the concept of steady state and how it relates to continuous dosing. (2) Determine optimum dosing for an infused drug by calculating pharmacokinetic parameters from clinical data. (3) Calculate loading doses to be used with an intravenous infusion. (4) Describe the purpose of a loading dose. 2.技能（能力）目标： (1) Be able to calculate pharmacokinetic parameters from clinical data. (2) Improve the skills in listening and speaking English in pharmacokinet ics 二、授课内容（依据教学大纲）及时间分配 Lecture I & II: One-compartment model drugs, infusion method for calculating patient elimination half -life,loading dose plus iv infusion-onecompartment model,estimation of drug clearance and VD from infusion data—100 min 三、教学重点与难点 教学重难点
Pharmacokinetic parameters for one-compartment model drugs after intravenous infusion,loading dose,est imation of drug clearance and Vo. 四、敦学方法选舞 1.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） (1)Use case study to explain the principles and applications of one-compartment model drugs after intravenous infusion, loading dose. (2)Review the major concepts and materials covering the chapters. (3)Work on problems with students together to emphasize the basic principles covered in the chapters (4)Test could push students usually. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1)Ask questions during case studies before and after introducing basic concepts (2)Discuss the complicated concepts (3)Solve problems together with students 2.实验课教学 No applicable. 五、更新或补充内容提要 课后总结：按照实际进度对知识点分详略进行讲解
Pharmacokinetic parameters for one-compartment model drugs after intravenous infusion, loading dose,estimation of drug clearance and VD. 四、教学方法选择 1.理论课堂教学 A.多媒体教学：（简要列出本章节多媒体教学设计特点及优势） (1) Use case study to explain the principles and applications of one-compartment model drugs after intravenous infusion, loading dose. (2) Review the major concepts and materials covering the chapters. (3) Work on problems with students together to emphasize the basic principles covered in the chapters (4) Test could push students usually. B.互动教学：（根据实际情况列出案例/实例讨论、分析讨论、分组讨论、翻转课堂等互动教学内容标题） (1) Ask questions during case studies before and after introducing basic concepts (2) Discuss the complicated concepts (3) Solve problems together with students 2.实验课教学 No applicable. 五、更新或补充内容提要 课后总结：按照实际进度对知识点分详略进行讲解