认识顽症预防肿瘤 生命学院王莲芸教授
认识顽症预防肿瘤 生命学院 王莲芸教授 1
2018诺贝尔奖专题|至少10多万人的生命得 到延续，这两个科学家摸到了癌细胞的命门 THE NOBEL PRIZE IN PHYSIOLOGY OR MEDICINE 2018 川陀空 2
2018诺贝尔奖专题｜至少10多万人的生命得 到延续，这两个科学家摸到了癌细胞的命门 2
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine A subcutaneous model of colon carcinoma(MC-26 cells)was Immunohistochemistry of a human established in immunocompetent BALB/c mice.Bacteria expressing PDAC tumor using an antibacterial luciferase were injected intravenously LPS antibody.Arrows point to LPS and selectively detected in the tumors staining in the tumor tissue with IVIS. 3
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine 3 Immunohistochemistry of a human PDAC tumor using an antibacterial LPS antibody. Arrows point to LPS staining in the tumor tissue A subcutaneous model of colon carcinoma (MC-26 cells) was established in immunocompetent BALB/c mice. Bacteria expressing luciferase were injected intravenously and selectively detected in the tumors with IVIS
Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine Fluorescence in situ hybridization was used to detect bacterial 16S rRNA sequences in a human PDAC tumor (red). Cell nuclei were stained with 4,6- diamidino-2-phenylindole(DAPI) (blue). Four sections from one tumor are presented. Scale bars,10 mm. 感染猪鼻支原体 4
Fluorescence in situ hybridization was used to detect bacterial 16S rRNA sequences in a human PDAC tumor (red). Cell nuclei were stained with 4′,6- diamidino-2-phenylindole (DAPI) (blue). Four sections from one tumor are presented. Scale bars, 10 mm. 4 Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine 感染猪鼻支原体
2015年中国癌症地图 肺癌仍居发病率死亡率首位 其次是胃癌 度管癌和肝癌也是引起死亡的 原因 男性前列腺癌发病率明显上升 女性癌症发病率第一位的是乳 腺癌 。Urban registry Rural registry > 按照平均寿命74岁计算，人一 ■North China ☐ortheast East China Central China South China ■Nor thuest 生中患恶性肿瘤的几率是22% > 肿瘤已经成为一种常见疾病 5
2015年中国癌症地图 肺癌仍居发病率死亡率首位 其次是胃癌 食管癌和肝癌也是引起死亡的 原因 男性前列腺癌发病率明显上升 女性癌症发病率第一位的是乳 腺癌 按照平均寿命74岁计算，人一 生中患恶性肿瘤的几率是22% 肿瘤已经成为一种常见疾病 5