NATURAL PRODUCT COMMUNICATIONS An International Journal for Communications and Reviews Covering all Aspects of Natural Products Research ANALYTICAL BIO- SYNTHESIS TECHNOLOGY BIODIVERSITY BIOACTIVITY &SAR NPC BIOSYNTHESIS PHARMACO- LOGY MOLECULAR CHEMICAL STRUCTURE ECOLOGY This Issue is Dedicated to the Memory of Professor Ivano Morelli Volume 1. Issue 12. 2006 ISSN 1555-9475(online) www.naturalproduct.us
Volume 1. Issue 12. 2006 ISSN 1555-9475 (online) www.naturalproduct.us This Issue is Dedicated to the Memory of Professor Ivano Morelli
NPC Natural Product Communications EDITOR-IN-CHIEF DR PAWAN K AGRAWAI ADVISORY BOARD 963.And EDITORS and f A.A.Ledie ALBERTO MARCO Prof, 好 HIRO MIMAKI f.Jera roE.M HIRO TEZUKA n-Kyu Le Prof.Hiromitsu Takayam INFORMATION FOR AUTHORS Authors h
INFORMATION FOR AUTHORS Full details of how to submit a manuscript for publication in Natural Product Communications are given in Information for Authors on our Web site http://www.naturalproduct.us. Authors may reproduce/republish portions of their published contribution without seeking permission from NPC, provided that any such republication is accompanied by an acknowledgment (original citation)-Reproduced by permission of Natural Product Communications. Any unauthorized reproduction, transmission or storage may result in either civil or criminal liability. The publication of each of the articles contained herein is protected by copyright. Except as allowed under national “fair use” laws, copying is not permitted by any means or for any purpose, such as for distribution to any third party (whether by sale, loan, gift, or otherwise); as agent (express or implied) of any third party; for purposes of advertising or promotion; or to create collective or derivative works. Such permission requests, or other inquiries, should be addressed to the Natural Product Inc. (NPI). A photocopy license is available from the NPI for institutional subscribers that need to make multiple copies of single articles for internal study or research purposes. To Subscribe: Natural Product Communications (ISSN# 1555-9475) is a journal published monthly. 2006 subscription price: US$1,095 (Web edition); US$1,395 (Print); US$1,795 (Print + single site online). Orders should be addressed to Subscription Department, Natural Product Communications, 7963 Anderson Park Lane, Westerville, Ohio 43081, USA. Subscriptions are renewed on an annual basis. Claims for nonreceipt of issues will be honored if made within three months of publication of the issue. All issues are dispatched by airmail throughout the world, excluding the USA and Canada. NPC Natural Product Communications EDITOR-IN-CHIEF DR. PAWAN K AGRAWAL Natural Product Inc. 7963, Anderson Park Lane, Westerville, Ohio, 43081 USA agrawal@naturalproduct.us EDITORS PROFESSOR GERALD BLUNDEN The School of Pharmacy & Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT U.K. gands@ surefish.co.uk PROFESSOR ALESSANDRA BRACA Dipartimento di Chimica Bioorganicae Biofarmacia, Universita di Pisa, via Bonanno 33, 56126 Pisa, Italy Email: braca@farm.unipi.it PROFESSOR DEAN GUO State Key Laboratory of Natural and Biomimetic Drugs, Shool of Pharmaceutcal Sciences, Peking University, Beijing 100083, China gda5958@163.com PROFESSOR ERNST HASLINGER Institute of Pharmaceutical Chemistry, University of Graz, A-8010 Graz, Austria Ernst.Haslinger@uni-graz.at PROFESSOR J. ALBERTO MARCO Departamento de Quimica Organica, Universidade de Valencia, E-46100 Burjassot, Valencia, Spain alberto.marco@uv.es PROFESSOR YOSHIHIRO MIMAKI School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachioji, Tokyo 192-0392, Japan mimakiy@ps.toyaku.ac.jp PROFESSOR M. G. REINECKE Deapartment of Chemistry, Texas Christian University, Forts Worth, TX 76129, USA m.reinecke@tcu.edu PROFESSOR YASUHIRO TEZUKA Institute of Natural medicine Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan tezuka@ms.toyama-mpu.ac.jp ADVISORY BOARD Prof. Oyvind Andersen Bergen, Norway Prof. Bruno Botta Roma, Italy Prof. Carlos Cerda-Garcia-Rojas Mexico city, Mexico Prof. Ioanna Chinou Athens, Greece Prof. Josep Coll Barcelona, Spain Prof. Geoffrey Cordell Chicago, IL, USA Prof. Samuel Danishefsky New York, NY, USA Dr. Biswanath Das Hyderabad, India Prof. Daneel Ferreira Mississippi, MS, USA Prof. A.A. Leslie Gunatilika Tucson, AZ, USA Prof. Stephen Hanessian Montreal, Canada Prof. Michael Heinrich London, UK Prof. Kurt Hostettmann Lausanne, Switzerland Prof. Martin A. Iglesias Arteaga Mexico, D. F, Mexico Prof. Norbert De Kimpe Gent, Belgium Prof. Jerzy Jaroszewski Copenhagen, Denmark Prof. Teodoro Kaufman Rosario, Argentina Prof. Marie Lacaille-Dubois Dijon, France Prof. Hartmut Laatsch Gottingen, Germany Prof. Hyeong-Kyu Lee Daejeon, Korea Prof. Shoei-Sheng Lee Taipei, Taiwan Prof. Chun-Nan Lin Kaohsiung, china Prof. Francisco Macias Cadiz, Spain Prof. Anita Marsaioli Campinas, Brazil Prof. Rachel Mata Mexico D. F., Mexico Prof. Imre Mathe Szeged, Hungary Prof. Joseph Michael Johannesburg, South Africa Prof. Virinder Parmar Delhi, India Prof. Luc Pieters Antwerp, Belgium Prof. Peter Proksch Düsseldorf, Germany Prof. Stephen Pyne Wollongong, Australia Prof. William Reynolds Toronto, Canada Prof. Raffaele Riccio Salerno, Italy Prof. Ricardo Riguera Santiago de Compostela, Spain Prof. Satyajit Sarker Coleraine, UK Prof. Monique Simmonds Richmond, UK Prof. Valentin Stonik Vladivostok, Russia Prof. Hermann Stuppner Innsbruck, Austria Prof. Apichart Suksamrarn Bangkock, Thailand Prof. Hiromitsu Takayama Chiba, Japan Prof. Paul Wender Stanford, USA
Natural Product Communications Vol.1(12)2006 Published online(www.naturalproduct.us) Editorial Special Issue in Memory of Professor Ivano Morelli The December issue duct Com ublis vidual by th e comes fr in this issu excepeed p essor Morel has played key phytochemical role in the de Ciopmentoi earch,not only within the Italy,but also in the international arena Many thanks go to the authors,who have contributed some of their finest work to a timetable that has been quite challenging,and to the manuscript reviewers for their help in making this issue a success. Finally the or ould like to pay theirt oute to the scholarly,scientific. and ment p roles of Profe and the
Natural Product Communications Vol. 1 (12) 2006 Published online (www.naturalproduct.us) Editorial Special Issue in Memory of Professor Ivano Morelli The December issue of Natural Product Communications is dedicated to Professor Ivano Morelli, an inspiration to scientists, young and old. The more enjoyable element of publishing this memorial issue comes from the recognition and tribute made to an exceptional individual by the many former students and colleagues who are authors of the papers in this issue. Indeed, Professor Morelli has played a key role in the development of phytochemical research, not only within the Italy, but also in the international arena. Many thanks go to the authors, who have contributed some of their finest work to a timetable that has been quite challenging, and to the manuscript reviewers for their help in making this issue a success. Finally, the editors would like to pay their tribute to the scholarly, scientific, and mentorship roles of Professor Ivano Morelli. Truly, his pursuit of scientific knowledge concerning organic chemistry and his dedication to his students and colleagues make him an exceptional individual worthy of our admiration, emulation, and the homage being paid to him in these pages of Natural Product Communications. Pawan K. Agrawal Editor-in-Chief
mications Vol.1(12)2006 Obituary Ivano Morelli (1940-2005) Prof.Ivano Morelli was born March 11,1940.in Pis ated from Pisa Un Pisa Uni versity. During his career he was appointed as Director of Bioorganic and Biopharmacy Department since 1986 when it was called Institute of Organic Chemistry;in the last years he was also member of the Academic Senate of Pisa University.He served the Italian Society of Phytochemistry as President in the years 1987-1989 and 2004-2005.He His chemical work foct ides and dibro iring the as1966.197 to Rosa and Asteracae families ()studiofplant belongino veloping coumtrof Latin mrccaand Asia(1990-2005);analysis of essential oils of Apiaceae,Asteraceae,and Lamiaceae from 1990 until 2005
Natural Product Communications Vol. 1 (12) 2006 Published online (www.naturalproduct.us) Obituary Ivano Morelli (1940-2005) Prof. Ivano Morelli was born March 11, 1940, in Pisa, Italy. He graduated from Pisa University in 1965 and received an Assistant Professor position in Organic Chemistry in 1966. From 1980 until his death he was Full Professor of Phytochemistry at the Faculty of Pharmacy, Pisa University. During his career he was appointed as Director of Bioorganic and Biopharmacy Department since 1986 when it was called Institute of Organic Chemistry; in the last years he was also member of the Academic Senate of Pisa University. He served the Italian Society of Phytochemistry as President in the years 1987-1989 and 2004-2005. He was also the Director of the School of Science and Technology of Medicinal Plants of Pisa University from 1985 until 2001 (the year of its disactivation) and Director of several PhD courses during the last 10 years. His chemical work focused on the study of mosses and reaction mechanisms of epoxides and dibromocyclohexanes during the years 1966-1978; chemical studies of Mediterranean plants belonging to Rosaceae, Apiaceae, and Asteraceae families (1978-1990); studies of plants belonging to developing countries of Latin America, Africa, and Asia (1990-2005); analysis of essential oils of Apiaceae, Asteraceae, and Lamiaceae from 1990 until 2005
Obitary/Natral Product Communications Vol.1(12)2006 clos and he k :a man of few words.but open-hearted.hone to listen the ive suggestions.but at the same time.he knew how to ask suggestions.in a mutual opinions excha His o mindedness,curiosity,diplomacy,and passion brought him far,to Asia.Europe,and America,taking his scientific cooperation and opening his laboratory to many young researchers from different countries.He gives the opportunity to the young scientists to work without any restriction,giving hospitality to any people and to their opinions,since he was researcher of all the"human activities".His contribution to the knowle dge of the plants longing to Italian an international flora is great but his love for the teaching.the research,the University,and the co-workers was grea An inexorable leukemia took him far from his dear the 18 april 2005.He is survived by his wife lolena and two sons.Marco and llaria.His love for the phytochemistry was stronger than the fear of his disease:he continued to be present among us even if he was far from the Department,during his hard time in the hospital.He had never stopped to fight:his brave heart was a daily teaching.The death obliged him to rest but never the death prevented him from teaching us his last lesson of life. Alessandra Braca partimento diChmc via Bonanno 33,56126 Pisa. Italy
Obituary / Natural Product Communications Vol. 1 (12) 2006 We remember him as a very active scientist and an eclectic man: a man of few words, but open-hearted, honest, concrete, and fair. The wellbeing of his collaborators, students, and friends was for him one of the most important thoughts. The door of his office was never closed and he knew how to listen the requests of everyone. He liked to give suggestions, but at the same time, he knew how to ask suggestions, in a mutual opinions exchange. His openmindedness, curiosity, diplomacy, and passion brought him far, to Asia, Europe, and America, taking his scientific cooperation and opening his laboratory to many young researchers from different countries. He gives the opportunity to the young scientists to work without any restriction, giving hospitality to any people and to their opinions, since he was researcher of all the “human activities”. His contribution to the knowledge of the plants belonging to Italian and international flora is great but his love for the teaching, the research, the University, and the co-workers was great. An inexorable leukemia took him far from his dear the 18 April 2005. He is survived by his wife, Iolena, and two sons, Marco and Ilaria. His love for the phytochemistry was stronger than the fear of his disease; he continued to be present among us even if he was far from the Department, during his hard time in the hospital. He had never stopped to fight: his brave heart was a daily teaching. The death obliged him to rest but never the death prevented him from teaching us his last lesson of life. Alessandra Braca Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, via Bonanno 33, 56126 Pisa, Italy