Example: development of cancer of the epithelium of the uterine cervix LOW-GRADE HIGH-GRADE NORMAL EPITHELIUM INTRAEPITHELIAL INTRAEPITHELIAL INVASIVE CARCINOMA NEOPLASIA NEOPLASIA 〓Me=g2 (C) (D) Benign Malignant Adapted from Molecular Biology of the Ce// 5th edition
Adapted from Molecular Biology of the Cell 5th edition Example: development of cancer of the epithelium of the uterine cervix Benign Malignant
Cancer originating from different origin are, in general very different diseases oral cavI and pharynx digestive organs cancers of respiratory epithelia system carcinomas reproductive urinary kin melanoma leukemias and lymphomas ste KEYA new cases deaths/year connective tissue, other 200 300 number per year (thousands) Incidence and mortality of different cancers in the United States. Data from American Cancer Society, 2004 Adapted from Molecular Biology of the Ce// 5th edition
◼ Cancer originating from different origin are, in general, very different diseases. Incidence and mortality of different cancers in the United States. Data from American Cancer Society , 2004. Adapted from Molecular Biology of the Cell 5th edition
Part 1 summary 1). The basic concepts Benign and malignant tumor Cancer cells reproduce without restraint and colonize other tissues 2). Cancer is a very complex and virulent disease Cancer is becoming the leading cause of death worldwide a There are large variety kinds of cancer which can be classified by their tissue or cell origin Different types of cancer can be considered as very different disease
Part 1 summary 1). The basic concepts ▪ Benign and malignant tumor ▪ Cancer cells reproduce without restraint and colonize other tissues 2). Cancer is a very complex and virulent disease ▪ Cancer is becoming the leading cause of death worldwide. ▪ There are large variety kinds of cancer which can be classified by their tissue or cell origin. ▪ Different types of cancer can be considered as very different disease
2. What Causes Cancer Chemical Exposure Behavior(Tobacco smoke -> lung cancer) Environmental (polychlorinated biphenyl,(PCBs) Occupational (coal tar, asbestos aniline dye) Diet (aflatoxin-> liver cancer Radiation(UV-> Xeroderma pigmentosum, ionizing Infection Viruses(Epstein-Barr virus(EBv)-> lymphoma, hepatitis B->liver cancer, papilloma-> cervical cancer etc) Inherited familial cancer syndromes Mutations and or chromosomal abnormalities Most, if not all, of these causes have their genetic underpinning linked with cancer
2. What Causes Cancer? • Chemical Exposure – Behavior (Tobacco smoke -> lung cancer) – Environmental (polychlorinated biphenyl, (PCBs)) – Occupational (coal tar, asbestos, aniline dye) – Diet (aflatoxin -> liver cancer) • Radiation (UV -> xeroderma pigmentosum,ionizing) • Infection – Viruses (Epstein–Barr virus (EBV) -> lymphoma, hepatitis B -> liver cancer, papilloma -> cervical cancer etc) • Inherited familial cancer syndromes • Mutations and/or chromosomal abnormalities Most, if not all, of these causes have their genetic underpinning linked with cancer
Aflatoxin b can directly reacting with on DNA and induce mutations Is a toxin from mold that grows on grain and peanuts when stored in humid tropical conditions and a contributory cause of live cancer in the tropics with a characteristic mutations in TP53 OH cytochrome P-450 OCH OCH H2N DNA AFLATOXIN AFLATOXIN-2, 3-EPOXIDE CARCINOGEN BOUND TO GUANINE IN DNA Figure 20-22a Molecular Biology of the Cell 5/e(o Garland Science 2008)
◼ Aflatoxin B can directly reacting with on DNA and induce mutations - Is a toxin from mold that grows on grain and peanuts when stored in humid tropical conditions; - and a contributory cause of live cancer in the tropics with a characteristic mutationsin TP53