core histoneslinkerDNAofnucleosome"beads-on-a-string"nucleosome includes-200 nucleotideform.ofchromatinpairs of DNANUCLEASEDIGESTSLINKERDNA4released11nmnucleosomecoreparticle+DISSOCIATIONWITHHIGHCONCENTRATIONOFSALT25octameric146-nucleotide-pairhistone coreDNAdoublehelixDISSOCIATION?C2H2AH2BH3H4
NucleosomecoreparticleLinkerDNA146bpHistoneH1Nucleosome
AAAIATITA/TTCCICG/GCIGG0.280.260.240.22-60-40-202040600Locationrelativetocenteralignmentofnucleosomereads(bp)B江旺门认
8AMNaseTrinucleosomesDinucleosomesMononucleosomes10000OOOOOOOOoOOOOOOooOooOoOOOOOOODOOOO00-oOooOooooeBeoooooooeee223promotersChrlll