Pathophysiology 癖 Abnormal tissues— tumor,AVM,dead area These regions of the brain may promote development of novel hyperexcitable synapses that can cause seizures
Pathophysiology Abnormal tissues — tumor, AVM, dead area These regions of the brain may promote development of novel hyperexcitable synapses that can cause seizures
Pathophysiology 秦 Genetic factors At least 20 Some examples e Benign neonatal convulsions--20q and 8a Juvenile myoclonic epilepsy--6p Progressive myoclonic epilepsy--21g223
Pathophysiology Genetic factors At least 20 % Some examples Benign neonatal convulsions--20q and 8q Juvenile myoclonic epilepsy--6p Progressive myoclonic epilepsy--21q22.3
Pathophysiology a Role of substantia nigra Studies with 2-deoxyglucose indicate that a marked increase in metabolic activity in SN is a common feature of several types of generalized seizures; it is possible that some of this increased activity is associated with GABAergic nerve terminals that become activated in an attempt to suppress seizure spread Because gaba has been shown to inhibit nigral efferents, it is likely that gaba terminals inhibit nigral projections that are permissive or facilitative to seizure propagation From Gale K. Role of the substantia nigra in gABa mediated anticonvulsant actions. Adv Neuro.1986:44:343-364
Pathophysiology Role of substantia nigra Studies with 2-deoxyglucose indicate that a marked increase in metabolic activity in SN is a common feature of several types of generalized seizures; it is possible that some of this increased activity is associated with GABAergic nerve terminals that become activated in an attempt to suppress seizure spread. Because GABA has been shown to inhibit nigral efferents, it is likely that GABA terminals inhibit nigral projections that are permissive or facilitative to seizure propagation From Gale K. Role of the substantia nigra in GABAmediated anticonvulsant actions. Adv Neurol.1986;44:343-364
Pathophysiology Premature brain It is more susceptible to specific seizures than is the brain in older children and adults 纛 Kindling Repeated subconvulsive stimulation( e.g. to the amygdala)will lead to generalized convulsion e This may explain the development of epilepsy after injury to the brain e One temporal lobe seizure - contralateral lobe
Pathophysiology Premature brain It is more susceptible to specific seizures than is the brain in older children and adults Kindling Repeated subconvulsive stimulation (e.g. to the amygdala) will lead to generalized convulsion This may explain the development of epilepsy after injury to the brain One temporal lobe seizure -> contralateral lobe
Classification of seizures
Classification of seizures