Aetiology of seizures epileptic Idiopathic(70-80%) Cerebral tumor Neurodegenerative disorders Neurocutaneous syndromes Secondary to Cerebral damage: e.g. congenital infections HIE, intraventricular hemorrhage Cerebral dysgenesis/malformation: e.g hydrocephalus
Aetiology of seizures ▪ Epileptic ▪ Idiopathic (70-80%) ▪ Cerebral tumor ▪ Neurodegenerative disorders ▪ Neurocutaneous syndromes ▪ Secondary to ▪ Cerebral damage: e.g. congenital infections, HIE, intraventricular hemorrhage ▪ Cerebral dysgenesis/malformation: e.g. hydrocephalus
Aetiology of seizures Non-epileptic Febrile convulsions Metabolic Hypoglycemia HypoCa, HypoMg, HyperNa, HypoNa Head trauma Meningitis Encephalitis Poisons/toxins
Aetiology of seizures ▪ Non-epileptic ▪ Febrile convulsions ▪ Metabolic ▪ Hypoglycemia ▪ HypoCa, HypoMg, HyperNa, HypoNa ▪ Head trauma ▪ Meningitis ▪ Encephalitis ▪ Poisons/toxins
t Aetiology of Status Epilepticus Prolonged febrile seizure a Most common cause Idiopathic status epilepticus Non-compliance to anti-convulsants Sudden withdrawal of anticonvulsants Sleep deprivation e Intercurrent infection Symptomatic status epilepticus e Anoxic encephalopathy Encephalitis, meningitis e Congenital malformations of the brain e Electrolyte disturbances, drug/lead intoxication, extreme hyperpyrexia, brain tumor
Aetiology of Status Epilepticus Prolonged febrile seizure Most common cause Idiopathic status epilepticus Non-compliance to anti-convulsants Sudden withdrawal of anticonvulsants Sleep deprivation Intercurrent infection Symptomatic status epilepticus Anoxic encephalopathy Encephalitis, meningitis Congenital malformations of the brain Electrolyte disturbances, drug/lead intoxication, extreme hyperpyrexia, brain tumor
Pathophysiology still unknown Some proposals EXcitatory glutamatergic synapses EXcitatory amino acid neurotransmitter (glutamate, aspartate) Abnormal tissues tumor. avm, dead area Genetic factors Role of substantia nigra and gaba
Pathophysiology Still unknown Some proposals: Excitatory glutamatergic synapses Excitatory amino acid neurotransmitter (glutamate, aspartate) Abnormal tissues — tumor, AVM, dead area Genetic factors Role of substantia nigra and GABA
Pathophysiology t EXcitatory glutamatageric synapses t And, excitatory amino acid neurotransmitter(glutamate, aspartate These are for the neuronal excitation e In rodent models of acquired epilepsy and in human temporal lobe epilepsy, there is evidence for enhanced functional efficacy of ionotropic N-methyl-D-aspartate (NMDA)and metabotropic(Group I)receptors ChapmanAG Glutatmate and Epilepsy. J Nutr. 2000 Apr; 1304 S Supp):1043S-5S
Pathophysiology Excitatory glutamatageric synapses And, excitatory amino acid neurotransmitter (glutamate, aspartate) These are for the neuronal excitation In rodent models of acquired epilepsy and in human temporal lobe epilepsy, there is evidence for enhanced functional efficacy of ionotropic N-methyl-D-aspartate (NMDA) and metabotropic (Group I) receptors Chapman AG. Glutatmate and Epilepsy. J Nutr. 2000 Apr; 130(4S Suppl): 1043S-5S