Pathogenesis gastrointestinal tract host-pathogen interactions The amount of bacilli infection (>105baeteria)
Pathogenesis ◼ gastrointestinal tract host-pathogen interactions ◼ The amount of bacilli infection (>105baeteria)
Pathogenesis ingested orally Stomach barrier(some Eliminated) enters the small intestine ->Penetrate the mucus layer -enter mononuclear phagocytes of ileal peyer's patches and mesenteric lymph nodes -proliferate in mononuclear phagocytes spread to blood.initial bacteremia(Incubation period)
ingested orally → Stomach barrier (some Eliminated) → enters the small intestine →Penetrate the mucus layer → enter mononuclear phagocytes of ileal peyer's patches and mesenteric lymph nodes → proliferate in mononuclear phagocytes spread to blood. initial bacteremia (Incubation period). Pathogenesis
Pathogenesis -enter spleen,liver and bone marrow (reticulo- endothelial system) further proliferation occurs -A lot of bacteria enter blood again. (second bacteremia). →Recovery
Pathogenesis → enter spleen, liver and bone marrow (reticuloendothelial system) further proliferation occurs → A lot of bacteria enter blood again. (second bacteremia). → Recovery
S.Typhi. liver、spleen、gal BM,ect 2nd bacteremia early stage&acme stage 1-3YD stomach (monon 军器内的 微绒毛状突起 Bac.In gall uclear D phagoc 于某物上 ytes) 被吞噬的红阳的 吞壁细胞的扫描电镜式图 Bac.In Lower teces ileum peyer's patches S.Typhi eliminated mesenteric lymph nodes onvalvescence stag (4-5w LN Proliferate,swell 1st bacteremia necrosis defervescence stage thoraci (Incubation stage) Enterorrhagia,i ntestinal (3-4w) duct 10-14d perforation
S.Typhi. stomach Lower ileum peyer's patches & mesenteric lymph nodes thoracic duct 1st bacteremia (Incubation stage) 10-14d (monon uclear phagoc ytes ) 2nd bacteremia liver、spleen、gall、 BM ,ect early stage&acme stage (1-3W） LN Proliferate,swell necrosis defervescence stage （3-4w） Bac. In gall Bac. In feces S.Typhi eliminated convalvescence stage (4-5w) Enterorrhagia,i ntestinal perforation
Pathology ■ essential lesion: proliferation of RES (reticuloendothelial system specific changes in lymphoid tissues and mesenteric lymph nodes. "typhoid nodules" Most characteristic lesion: ulceration of mucous in the region of the Peyer's patches of the small intestine
Pathology ◼ essential lesion: proliferation of RES (reticuloendothelial system ) specific changes in lymphoid tissues and mesenteric lymph nodes. "typhoid nodules“ ◼ Most characteristic lesion: ulceration of mucous in the region of the Peyer’s patches of the small intestine