Major Features of TTV Virion: Nonenveloped virus Nucleic acid:3.7 kb,a single-stranded DNA molecule Genus: Circoviridae family Pathogenicity:Indefinite
Major Features of TTV Virion: Nonenveloped virus Nucleic acid: 3.7 kb, a single-stranded DNA molecule Genus: Circoviridae family Pathogenicity: Indefinite
THE VIRUS HAV:linear single stranded RNA,heparnavirus HBV:circular partially double stranded DNA molecule,hepadnavirus HCV:single stranded RNA molecule,flavivirus HDV:circular single stranded RNA molecule HEV:single stranded RNA molecule HGV:single stranded RNA molecule,flavivirus too TTV:single stranded DNA molecule
THE VIRUS HAV: linear single stranded RNA, heparnavirus HBV: circular partially double stranded DNA molecule, hepadnavirus HCV: single stranded RNA molecule, flavivirus HDV: circular single stranded RNA molecule HEV: single stranded RNA molecule HGV: single stranded RNA molecule, flavivirus too TTV: single stranded DNA molecule
EPIDEMIOLOGY Global Patterns of HAV Transmission Endemicity Disease Peak Age of Transmission Rate Infection Patterns High Low to Early childhood Person to person high fecal-oral Moderate High Late childhood/ Person to person; young adults foodborne and waterborne outbreaks Low Low Young adults Person to person Very low Very low Adults Travelers; outbreaks uncommon
EPIDEMIOLOGY Global Patterns of HAV Transmission Endemicity Disease Peak Age of Transmission Rate Infection Patterns High Low to Early childhood Person to person high ( fecal-oral ) Moderate High Late childhood/ Person to person; young adults foodborne and waterborne outbreaks Low Low Young adults Person to person Very low Very low Adults Travelers; outbreaks uncommon
Prevalence of HBV in The World All over the world:Chronic HBV carriers>0.35 billions, about 5%of the world populations. Asia Africa:Chronic HBV carriers are 8%~20%. in which,about 50%~70%are chronic hepatitis B China:Chronic HBV carriers are 9.75%,in which, chronic hepatitis B:about 30 millions about 10%-20%may develop to liver cirrhosis,and 1%~5%lead to hepatocellular carcinoma(HCC)
Prevalence of HBV in The World All over the world: Chronic HBV carriers>0.35 billions， about 5% of the world populations. Asia & Africa: Chronic HBV carriers are 8%~20%, in which, about 50%~70% are chronic hepatitis B. China: Chronic HBV carriers are 9.75%, in which, chronic hepatitis B: about 30 millions， about 10%-20% may develop to liver cirrhosis, and 1%~5% lead to hepatocellular carcinoma(HCC)
Prevalence of chronic HBV carrier in some nations or areas Chronic HBV carriers(million) China 120.0 India 48.0 Indonesia 11.6 Philippine 7.6 Taiwan 3.0 South Korea 2.5 Japan 1.3 Hongkong 0.7 Australia 0.2 Singapore 0.03
Prevalence of chronic HBV carrier in some nations or areas Chronic HBV carriers(million) China 120.0 India 48.0 Indonesia 11.6 Philippine 7.6 Taiwan 3.0 South Korea 2.5 Japan 1.3 Hongkong 0.7 Australia 0.2 Singapore 0.03