Il. pathogenesis of ischemia-reperfusion InJury 1. The role of free radical (1 kinds and concept of free radical free radical:
Ⅱ. pathogenesis of ischemia-reperfusion injury 1. The role of free radical ⑴ kinds and concept of free radical free radical:
normal: o +4e+4H*t 2H0 、O、,e+21x e+h+ e+H O2° HO →OH
normal: O2 +4e+4H+ 2H2O O2 →O - • 2 H2O2 OH • H2O e - e - + 2H + e - + H + e - + H + H2O
oxygen free radical: O°,、OH ki nas o (active oxygen: 02- H202-OH) free radical lipid free radical: L、LO∵、LOO° others:Cr、CH、NO
oxygen free radical: O - • 2 、OH • kinds of (active oxygen: 1O2、H2O2 OH • ) free radical lipid free radical: L• 、LO• 、LOO• others: Cl• 、CH3 • 、NO
(2)mechanism of increase of oxygen free radical O formation of oxygen free radical nature oxidation of Hb, Cwt C 0,-0,=0,=OH=,O HO oxidation of enzyme: xanthine oxidase(XO) xanthine uric acid OO Mitochondria: o
(2) mechanism of increase of oxygen free radical ① formation of oxygen free radical nature oxidation of Hb , Cyt C O2 O ‾∙ 2 H2O2 OH∙ H2O H2O oxidation of enzyme : xanthine oxidase(XO) O ‾∙ 2 xanthine uric acid O2 O ‾∙ 2 Mitochondria: O ‾∙ 2