Oxvgen paradox Hypoxia liquid perfuse organ or culture without oxygen In jury restore perfusion evere inlury
Oxygen paradox Hypoxia liquid perfuse organ or culture without oxygen injury restore perfusion severe injury
I. Cause of ischemia-reperfusion injur y and affecting factor coronary in spasm + antispasmotic thrombosis thrombolytic therapy 1. cause coronary by-pass operation on heart: no-reflow organ transplant
Ⅰ. Cause of ischemia-reperfusion injur y and affecting factor coronary in spasm antispasmotic thrombosis thrombolytic therapy 1. cause coronary by-pass operation on heart: no-reflow organ transplant
2. Affecting factor small 5-10min: arrhythmia (1)ischemic(animals 20-30min: ventricular tremor time bi 20-40min: reversible injury animals 40-60min: irreversible InJury diversity between small and big animal
2．Affecting factor small 5-10min: arrhythmia ⑴ ischemic animals 20-30min: ventricular time tremor big 20-40min: reversible injury animals 40-60min: irreversible injury diversity between small and big animal
I0% 閎图 对照 缺血 缺血加再灌 ATP K 2 Changes of ischemic perfuse:ATP、Ca2+、k+
Changes of ischemic perfuse: ATP、Ca2 + 、K+
() collateral#) circulation: chronic (3)02 consumption rate K]會Mg21會 protection electrolytes Nat]Ca食da amage (5)condition of t, pressure, pH, Nat, Cazt protection reperfusion ( T, pressure, Nat, C a2+1-,damage
⑵ collateral(侧枝) circulation：chronic ⑶ O2 consumption rate [K+ ] , [Mg2+ ] protection ⑷ electrolytes [Na+ ] , [Ca2+ ] damage (5) condition of T, pressure,pH,Na+ ,Ca2+ protection reperfusion T, pressure,Na+ ,Ca2+ damage