Department of Electronic Engineering Tsinghua University A Heterogeneous Accelerator Platform for Multi-subject Voxel-based Brain Network Analysis Yu WANG, Mo XU, Ling REN, Xiaorui ZHANG, Di WU, Yong HE, Ningyi XU, Huazhong YANG Joint work by tsinghua Univ, beijing normal University, and microsoft NIES Nano-scale Integrated Circuit and System Lab
Department of Electronic Engineering, Tsinghua University Nano-scale Integrated Circuit and System Lab. A Heterogeneous Accelerator Platform for Multi-subject Voxel-based Brain Network Analysis Yu WANG, Mo XU, Ling REN, Xiaorui ZHANG, Di WU, Yong HE, Ningyi XU, Huazhong YANG Joint work by Tsinghua Univ., Beijing Normal University, and Microsoft 1
Outline Background and motivation a What is the brain network Platform and algorithm Why and how we design accelerators Results Conclusion and future work a What we can do next
Outline ➢ Background and Motivation ❑ What is the brain network ➢ Platform and Algorithm ❑ Why and how we design accelerators ➢ Results ➢ Conclusion and future work ❑ What we can do next 2
Understanding the brain One of the greatest scientific challenges of 21st century Human Genome Project(HGP 1990-2003) a NIH Human Connectome Project http://humanconnectome.org/ThenIHHumanConnectomeProjectwowmc Human Connectome Project Connectome Mupping structural and functional conection in the hunan brain Human Connectome Mapping structural and functional connectivity in the human brain 5 years, $30 million, 2 consortiums, 4+ universities /hospitals for the basic analysis method and acquiring data Washington University in Saint Louis- Univeraity ofMinneswta
Understanding the Brain ➢ One of the greatest scientific challenges of 21st century ❑ NIH Human Connectome Project 3 http://humanconnectome.org/ Human Connectome: Mapping structural and functional connectivity in the human brain 5 years, $30 million, 2 consortiums, 4+ universities/hospitals, for the basic analysis method and acquiring data Human Genome Project (HGP 1990-2003)
What are brain networks? What is a network? Nodes and connections are two basic elements of a network A network (graph) What are the nodes and connections of brain networks and how do we define them? How many types of brain network s are there according to scale, physiology, and anatomy
What are brain networks? ◼ What is a network? ➔ Nodes and connections are two basic elements of a network. ◼ What are the nodes and connections of brain networks and how do we define them? ◼ How many types of brain network s are there according to scale, physiology, and anatomy A network (graph)
Scales and levels of brain networks Basic structure of brain networks(node and connection can be defined at different scales Microscale: neurons and Mesoscale: connections Macroscale: anatomically their synaptic connections within and between distinct brain regions and (about 1010 neurons in the minicolumns(about 2x108 inter-regional pathways cortey ) inicolumn in the cortex about 100 regions in the Voxel based Brain network Analysis Basic elements can be derived from Medical Imaging echniques Scale Neurons Columns 10K-100K Sporns et al(2005)PLoS Comput Biol
Scales and levels of brain networks ◼ Basic structure of brain networks (node and connection) can be defined at different scales. Sporns et al (2005) PLoS Comput Biol Macroscale: anatomically distinct brain regions and inter-regional pathways (about 100 regions in the cortex). Columns Regions Mesoscale: connections within and between minicolumns (about 2×108 minicolumn in the cortex ). Neurons Microscale: neurons and their synaptic connections (about 1010 neurons in the cortex). Voxel based Brain network Analysis Basic elements can be derived from Medical Imaging Techniques Scale: 10K-100K