Neonatal respiratory Distress Syndrome(NRDS) Tongji Hospital L
Neonatal Respiratory Distress Syndrome (NRDS) Tongji Hospital
Neonatal Respiratory Distress Syndrome(RDs or: Hyaline Membrane Disease(HMD) Most common cause of respiratory failure in the first days Occurring in 1-2%o of newborn infants(GA 26-28W, 50% 30-3lw, less than 20-25%) Mortality 50%at 20 yrs ago, Survive 80-90%now High risk: IDM, GA<37w, multi preg, C-Section, asphyxia, cold stress, history of prior affected, male or white infants Low risk: chronic or pregnancy-associated hypertension, maternal opiate addiction, PROM, antenatal corticosteroid
Neonatal Respiratory Distress Syndrome (NRDS) or: Hyaline Membrane Disease (HMD) ➢ Most common cause of respiratory failure in the first days ➢ Occurring in 1~2% of newborn infants (GA 26~28w, 50%, 30~31w, less than 20~25%) ➢ Mortality ~50% at 20 yrs ago, Survive 80~90% now ➢ High risk: IDM, GA<37w, multi preg., C-section, asphyxia, cold stress, history of prior affected, male or white infants ➢ Low risk: chronic or pregnancy-associated hypertension, maternal opiate addiction, PROM, antenatal corticosteroid
Lung Development s Embryonic Lung development G Fetal lung Development (Pseudoglandular, Canalicular, Terminal Saccular) Postnatal Lung Development
Lung Development Embryonic Lung Development Fetal Lung Development (Pseudoglandular, Canalicular, Terminal Saccular) Postnatal Lung Development
Embryonic lung development Primary bronchial Esophagus primitive lung main bronchi Bronchial buds Blood vessel Mesoderm 26-28 days 26-28 days Primary bron Trachea lobar bronchi Mesenchyme econdary(loban) enchyma Secondary (lobar bronch bronchus 4-5 weeks Esophagus Blood vesse pRimary bronchi Lobar bronch segmental bronchi Tertiary (segmental Lobar bronchus Primary bronchus
Embryonic Lung Development primitive lung main bronchi lobar bronchi segmental bronchi
Fetal Lung Development Pseudoglandular stage x7th-16th week Right primary bronc Left primary bronchus Myofibroblasts buds bronch 8的 Acuna bronchi Subsegmental bronchi G 7- 16 weeks Primitive bronchial tree Terminal bronchioles
Fetal Lung Development Pseudoglandular Stage ~ 7th – 16th week Primitive bronchial tree Terminal bronchioles