THREE INFLUENCES OF THROMBOSIS Endothelial injury(most important) Alone can induce thrombosis Alterations in normal flow Hypercoagulability. When the last two are both present, endothelial injury is not requisite
THREE INFLUENCES OF THROMBOSIS • Endothelial injury (most important). Alone can induce thrombosis. • Alterations in normal flow. • Hypercoagulability. When the last two are both present, endothelial injury is not requisite
Deficiency Bernard-Soulier Syndrome A Deficiency: GpIb Glanzmann Platelet Thrombasthenia Gpllb-llla Fibrinogen complex Endothelium G von Willebrands factor Deficiency von Willebrand's Subendothelium Disease
INTRINSIC PATHWAY EXTRINSIC PATHWAY (Hageman Facton Tisse Inury HMK ccnA 区x (Prothrombin Phospho pa surface Actie Inactin COMMON PATHWAY
• Fig 5-8
Endothelial iniury Ulcerative atherosclerosis Transmural myocardial infarction Vasculitis Trauma ● Radiation ● Bacterial toxins
Endothelial injury • Ulcerative atherosclerosis • Transmural myocardial infarction • Vasculitis • Trauma • Radiation • Bacterial toxins