Structural statistics from August, 2003 Classification Of Proteins 7 CLASSES (a, b, a/b, a+b 800 FOLDS domain structures 1.294 SUPERFAMILIES possible evolutionary relationship 2. 327 FAMILIES strong sequence homology 54.745 DOMAINS Murzin aG. se Brenner. t hubbard and c chothia. " SCoP. A Structural classification of proteins database for the Investigation of Sequences and Structures "J Mol Biol. 247, no. 4(7 April 1995): 536-40
Structural statistics from August, 2003 Classification Of Proteins 7 CLASSES (a,b,a/b,a+b…) 800 FOLDS domain structures 1,294 SUPERFAMILIES possible evolutionary relationship 2,327 FAMILIES strong sequence homology 54,745 DOMAINS Murzin, AG, SE Brenner, T Hubbard, and C Chothia. "SCOP: A Structural Classification of Proteins Database for the Investigation of Sequences and Structures." J Mol Biol. 247, no. 4 (7 April 1995): 536-40
Structural Classification Of all alpha Proteins all beta alpha/beta alpha beta 7 CLASSES multi-domain ( a, b, a/b, a+b.) membrane 800 FOLDS small domain structures coiled-coil 1.294 SUPERFAMILIES low-resolution possible evolutionary relationship peptide 2. 327 FAMILIES designed strong sequence homology 54.745 DOMAINS
Structural Classification Of Proteins 7 CLASSES (a,b,a/b,a+b…) 800 FOLDS domain structures 1,294 SUPERFAMILIES possible evolutionary relationship 2,327 FAMILIES strong sequence homology 54,745 DOMAINS all alpha all beta alpha/beta alpha + beta multi-domain membrane small coiled-coil low-resolution peptide designed
Structural Classification Of Proteins 7 CLASSES ( a, b, a/b, a+b.) 800 FOLDS same secondary structure elements same order, same connectivity domain structures 1.294 SUPERFAMILIES possible evolutionary relationship 2. 327 FAMILIES strong sequence homology 54.745 DOMAINS
Structural Classification Of Proteins 7 CLASSES (a,b,a/b,a+b…) 800 FOLDS same secondary structure elements, same order, same connectivity domain structures 1,294 SUPERFAMILIES possible evolutionary relationship 2,327 FAMILIES strong sequence homology 54,745 DOMAINS
PDB Growth in New Folds 4000 3500 500 2000 1500 1000 500 8鼠邕邕營§昌昌劉§劉員 Year structures submitted per year; new folds per year (note that PDB criteria for a new fold differ from SCOP
PDB Growth in New Folds structures submitted per year; new folds per year (note that PDB criteria for a new fold differ from SCOP)
Structural Classification Of Proteins 7 CLASSES (a, b, a/b, a+b.) Low sequence identity, but probable 800 FOLDS evolutionary relationship (e.g. based on domain structures structure or function 1.294 SUPERFAMILIES possible evolutionary relationship 2,327 FAMILIES strong sequence homology 54745 DOMAINS
Structural Classification Of Proteins 7 CLASSES (a,b,a/b,a+b…) Low sequence identity, but probable evolutionary relationship (e.g. based on 800 FOLDS domain structures structure or function) 1,294 SUPERFAMILIES possible evolutionary relationship 2,327 FAMILIES strong sequence homology 54,745 DOMAINS