基因的含义:不清,变化,复杂 Nimble gene: An Evolving Concept 三菜三 ) Parri Cnci Jres woton The nelle adits Ia DNaa enem Th kms ef perlata Meyer 三 Woart界d The Central oDor 三 如m poon au quan beguin rpk urbe edr. hu badm Introna and tni RNA splog wn de 销 acne in bwl gsGn中daan pnv b 9001 tkmorenatng spt eu in ad dui mer tl yan, sincang t pdka逆adle bugneameher ns uf dure ih aurwndnaaid
基因的含义：不清，变化，复杂
OPINION HUMAN GENOME AT TEN 质疑:(关于肿痛的) Point: Hypotheses first 基因组研究实在没有 There is little to show for all the time and money invested in genomic studies of cancer, says Robert Weinberg -and the approach is 什么值得吹嘘的。 undermining tried-and-tested ways of doing, and of building, science. Is it worth extinguishing 30 small-scale projects for an attack at the systems-wide level?"原因:缺乏功能 在系统水平上进行一提示,无法形成 次尝试而牺牲30个小假说 规模项目,是否值得? Counterpoint: Data first Large, unbiased genomic surveys are taking cancer therapeutics in directions that could never have been predicted by traditional molecular biology, says Todd Golub
在系统水平上进行一 次尝试而牺牲30个小 规模项目，是否值得？ 质疑：(关于肿瘤的) 基因组研究实在没有 什么值得吹嘘的。 原因：缺乏功能 提示，无法形成 假说
HGP后的 Genome仍然是一部无法解读 的“天书”。 Science 16 February 2001 Science 16 February 2001 vol.291n0.5507pp.1255-1257 VoL291n.5507pp.1257-1260 DO:10.1126/ science.1058969 Do:10.1126/ science291.5507.1257 VIEWPOINT VIEWPOINT GENE NUMBER SEQUENCE INTERPRETATION What If There Are Only 30, 000 Human Genes? Making Sense of the Sequence 如果只有3万个基因 搞清楚序列的功能意 怎么办? 义!
HGP后的Genome仍然是一部无法解读 的“天书”。 如果只有3万个基因， 怎么办？ 搞清楚序列的功能意 义！
Genome Sequencing (Asof6/25/04)(Asof7/2505)(Asof7/20/07)Asof6/29/08 (1128)(1496)(2680)(3825) genome projects 199(274)(579)827complete(includes(28)(36)(49)94 eukaryotes) 508 (728)(1285)1932 prokaryotic genomes in progress 421(494)(721)936 eukaryotic genomes in progress mall archaebacterium Nanoarchaeum eguitans 500kb Bacillus anthracis(anthrax 5228kb S cerivisiae(yeast) 12,069kb Arabidopsis thaliana 115,428kb Drosophila melanogasterfruit fly) 137,000kb Anopheles gambiae(malaria mosquito 278.000kb Oryza sativa(rice) 420,000kb Mus musculus(mouse 2,493,000kb Homo sapiens(human 2,900,000kb http://www.genomesonline.org
(As of 6/25/04) (As of 7/25/05) (As of 7/20/07)As of 6/29/08 (1128)(1496)(2680) (3825) genome projects: 199 (274)(579) 827complete (includes (28) (36) (49) 94 eukaryotes) 508 (728) (1285) 1932 prokaryotic genomes in progress 421 (494) (721) 936 eukaryotic genomes in progress small: archaebacterium Nanoarchaeum equitans 500 kb Bacillus anthracis (anthrax) 5228 kb S. cerivisiae (yeast) 12,069 kb Arabidopsis thaliana 115,428 kb Drosophila melanogaster (fruit fly) 137,000 kb Anopheles gambiae (malaria mosquito) 278,000 kb Oryza sativa (rice) 420,000 kb Mus musculus (mouse) 2,493,000 kb Homo sapiens (human) 2,900,000 kb http://www.genomesonline.org/ Genome Sequencing
Understanding the genome We know the sequence-but can we understand it? Anna Pavlovnas drawing room was gradually filling. The highest Petersburg society was assembled there: people differing widely in age and character but alike in the social circle to which they belonged. Prince Vasili s daughter the beautiful Helene, came to take her father to the ambassador s entertainment; she wore a ball dress and her badge as maid of honor. The youthful little Princess bolkonskaya, known as la femme la plus seduisante de Petersbourg, was also there. She had been married during the previous winter and being pregnant did not go to any large gatherings, but only to small receptions. Prince Vasili s son, Hippolyte, had come with Mortemart, whom he ntroduced. The Abbe Morio and many others had also come To each new arrival Anna Pavlovna said,You have not yet seen my aunt,or You do not know my aunt? and very gravely conducted him or her to a little old lady, wearing large bows of ribbon in her cap, who had come sailing in from another room as soon as the guests began to arrive; and slowly turning her eyes from the visitor to her aunt, Anna Pavlovna mentioned each ones name and then left them Tolstoy. War and Peace
We know the sequence—but can we understand it? Understanding the genome Anna Pavlovna's drawing room was gradually filling. The highest Petersburg society was assembled there: people differing widely in age and character but alike in the social circle to which they belonged. Prince Vasili's daughter, the beautiful Helene, came to take her father to the ambassador's entertainment; she wore a ball dress and her badge as maid of honor. The youthful little Princess Bolkonskaya, known as la femme la plus seduisante de Petersbourg, was also there. She had been married during the previous winter, and being pregnant did not go to any large gatherings, but only to small receptions. Prince Vasili's son, Hippolyte, had come with Mortemart, whom he introduced. The Abbe Morio and many others had also come. To each new arrival Anna Pavlovna said, "You have not yet seen my aunt," or "You do not know my aunt?" and very gravely conducted him or her to a little old lady, wearing large bows of ribbon in her cap, who had come sailing in from another room as soon as the guests began to arrive; and slowly turning her eyes from the visitor to her aunt, Anna Pavlovna mentioned each one's name and then left them. --Tolstoy, War and Peace