The best example of a morphogen is the gradient of BMP signaling that controls D-V tissue differentiation neural crest (ectoderm) somite(mesoderm) neural tube (ectoderm) notochord(mesoderm) gut cavity (lined G by endoderm) tail bud head lateral plate mesoderm endoderm and yolk eye epidermis (ectoderm) Figure 21-70. Molecular Biology of the Cell, 4th Edition
The best example of a morphogen is the gradient of BMP signaling that controls D-V tissue differentiation. Fig. 3a
Mesoderm(中胚层) cell differentiation is determined by a morphogen gradient of BMP. ventral dorsal Lateral plate Somite Notochord BMPs are members of the tGFB superfamily Fig 3b
Lateral plate Somite Notochord BMP signaling Mesoderm（中胚层） cell differentiation is determined by a morphogen gradient of BMP. BMPs are members of the TGFβ superfamily. ventral dorsal Fig. 3b
Genes specifically expressed in the dorsal blastopore lip(胚孔唇 Spemann organizer)of the gastrula(原肠胚) were cloned. ben--CDNA library Organizer-specific Genes dissected dorsal lip st 10 y4 gastrula
Fig. 4a Genes specifically expressed in the dorsal blastopore lip (胚孔唇Spemann organizer) of the gastrula（原肠胚）were cloned. Organizer-specific Genes
Chordin(脊索发生素) mRNA is expressed in Spemann’s organIzer. Chordin protein is secreted and diffuses in the embryo
Chordin（脊索发生素）mRNA is expressed in Spemann’s organizer. Chordin protein is secreted and diffuses in the embryo. Fig. 4b
Chordin is an antagonist(拮抗剂) that binds BMP growth factors in the extracellular space, inhibiting binding to cell surface receptors. Chordin establishes a BMP4 activity gradient at gastrula. Another protein, Noggin(头发生素), has similar activity Secreted antagonists diffuse and are used in development to generate morphogen gradients BMP4 +chd Chd or Cerberus Chordal inhibits Fig 5
Chordin is an antagonist（拮抗剂）that binds BMP growth factors in the extracellular space, inhibiting binding to cell surface receptors. Chordin establishes a BMP4 activity gradient at gastrula. Another protein, Noggin（头发生素）, has similar activity. Secreted antagonists diffuse and are used in development to generate morphogen gradients. Chordin inhibits Fig. 5