Outcomes of exposure to bacteria Transiently colonize in the person Permanently colonize in the person Induce disease Colonization f Infection ≠| nduce disease 暴露于细菌≠感染 ≠感染性疾病
Outcomes of exposure to bacteria • Transiently colonize in the person. • Permanently colonize in the person. • Induce disease. Colonization ≠ Infection ≠ Induce disease 暴露于细菌 ≠ 感染 ≠ 感染性疾病
Mechanisms of immunopathogenicity single toxin 3 lccal inwas veness invasion and locai toxicity 与致病性有关 与抗感染免疫有关 令与诊断有关 °与治疗有关 invis 与预防有关 legal invasiveness assisted by local toxicity Clostridium perfringens, Antibody anco and any mes which degrade extracelular mediated responses arn boah involved n atrix la. g. Staohrioenceus are:s, resistanc:. Adhesion/柔附 en Adhesion toxin产生毒素 Multiplication multiplication繁殖 繁殖、扩散 Toxn产生毒素
Adhesion/黏附 toxin产生毒素 entry Multiplication 繁殖、扩散 Adhesion multiplication 繁殖 Toxin 产生毒素 与致病性有关 与抗感染免疫有关 与诊断有关 与治疗有关 与预防有关
(一)侵袭力 1.细菌的表面结构 (1)黏附素:细菌表面与黏附相关的蛋白,与致病性 相关 菌毛 细胞壁成分:细菌表面的其他蛋白 如G菌的外膜蛋(OMP)和G+菌的细胞壁 黏附素受体:多为靶细胞表面的糖类或糖蛋白 为什么不是所有的EcO都能引起尿路感染? (2)荚膜:抗吞噬及抵抗体液中杀菌物质的作用 荚膜、微荚膜 免疫逃逸
（一）侵袭力 1.细菌的表面结构 （1）黏附素：细菌表面与黏附相关的蛋白，与致病性 相关 -菌毛 -细胞壁成分：细菌表面的其他蛋白. 如G -菌的外膜蛋（OMP)和G+菌的细胞壁 黏附素受体：多为靶细胞表面的糖类或糖蛋白 （2）荚膜：抗吞噬及抵抗体液中杀菌物质的作用 荚膜、微荚膜 免疫逃逸 为什么不是所有的E.coli 都能引起尿路感染？
细菌黏附 Bacterium 细菌各论时,欢迎 回“家”看看 adhesin receptor Epithelium Pili (Host cells) M protein F-protein 化脓性链球菌/S. pyogenes lipoteichoic acid fibronectin Epithelium
细菌黏附 adhesin Epithelium (Host cells) receptor Bacterium fibronectin Pili M protein F-protein lipoteichoic acid Epithelium 细菌各论时，欢迎 回“家”看看！ 化脓性链球菌/S. pyogenes
Adhesion of E coli Fimbriae(Pili) Uropathogenic strains of E. coll Type 1 pili(fimbriae) mannose Pili Flagella P pili( fimbriae Copyright e 2004 Dennis Kunkel. Microscopy, Inc galactose glycolipids glycoproteins Epithelium pyelonephritis-associated pili 20
20 Adhesion of E. coli Fimbriae (Pili) mannose Type 1 pili (fimbriae) galactose – glycolipids – glycoproteins P pili ( fimbriae) Pili Flagella Epithelium pyelonephritis-associated pili Uropathogenic strains of E. coli