Causes 1 Primary renal diseases Primary glomerular diseases, Primary tubular diseases, Interstitial nephritis, et al 2 Secondary renal lesion Circulatory system diseases, immunity siseases, metabolic diseases, hematopathy, et al
6 Causes: 1 Primary renal diseases Primary glomerular diseases, Primary tubular diseases, Interstitial nephritis, et al. 2 Secondary renal lesion Circulatory system diseases, immunity siseases, metabolic diseases, hematopathy, et al
Basic manifestation of renal insufficiency 1 Glomerular dysfunction 2 Tubular dysfunction 3 Endocrine dysfunction
7 • 1 Glomerular dysfunction • 2 Tubular dysfunction • 3 Endocrine dysfunction Basic manifestation of renal insufficiency
1 Glomerular dysfunction ①GFR i blood flow L i net filtration pressure L ii Kf L 2 Glomerular permselectivity L
8 1 Glomerular dysfunction • ①GFR – ⅰblood flow – ⅱnet filtration pressure – ⅲ Kf • ② Glomerular permselectivity
Kidney H&E. proximal tubules 家c c macula densa :个公 ,? capsular space
9
2 Tubular dysfunction ① proximal tubule Renal glycosuria, aminoaciduria, renal tubular acidOsiS, hypophys phatemia ② loop of henle Hypotonic or isotonic urine, polyuria ③ dista| tubule Acid-base and electrolyte disorders, polyuria
10 2 Tubular dysfunction ①proximal tubule Renal glycosuria, aminoaciduria, renal tubular acidosis, hypophosphatemia ②loop of Henle Hypotonic or isotonic urine, polyuria ③distal tubule Acid-base and electrolyte disorders, polyuria