FUDAN UNIVERSITY 【 Clinical features】 RF negtive low back pain and stiffness other joints enthesitis familial aggregation HLA-B27 related

【概述】- Overview 【定义】- Definition本病为低骨量和骨 组织微细结构破坏,致使骨的脆性增加和容 易发生骨折的一种常见的全身性骨代谢疾病 OP常见于老年人,是一种临床综合症,引 起的骨痛、骨病及骨折影响患者的生活质量 2001年NIH认为是OP骨强度的损害 使骨折的危险性增加的疾病。骨强度主要反 映骨密度和骨质量的完整性。骨质量包含骨 结构(几何学)、骨转换、骨损伤的积累( 细微骨折)和骨矿化等

Objective 1 Definition types and mechanism of osteoporosis 2 Diagnosis, prevention and treatment of osteoporosis 3 Etiology and epidemiology of osteoporosis

Concept of leukemia Definition aIt is the results of the tumor proliferation of heamotopoietic stem cells.(造血干细 胞) Leukemia is a malignant blood disorder. (not solid tumor) Date xie Yi, Hua Shan Hospital

DIAGNOSIS AND CLASSIFICATION Anemia is an absolute decrease in hematocrit, hemoglobin concentration,or the RBC count. Anemia is not a diagnosis, but a sign of underlying disease

Chapter three Chronic Obstructive Pulmonary Diseases (COPD) Chronic Bronchitis Obstructive Pulmonary Emphysema

DEFINITION HEART FAILURE the pathophysiological state in which the heart is unable to pump blood at a rate commensurate with the requirement of the metabolizing tissues or can do so only from an elevated filling pressure. Usually caused by a defect in myocardial contraction (myocardial failure)

Epidemiology 6th leading cause of death in U.S. Number one Among the infectious diseases 6 million patients annually in US Incidence 5~10/1,000/year Mortality in OPD patients 1-5 % but Inpatients 25%, ICU 50-60%

Classification of diabetes(ADA -1997) Type 1 .(beta-cell destruction, usually leading to absolute insulin deficiency) Autoimmune Idiopathic Type2 (may range from predominantly insulin resistance with relative insulin deficiency to a predominantly secretory defect with or without insulin resistance)

Respiratory failure Acute respiratory distress syndrome(ARDS) dyspnea Hypoxemia hypercapnia Respiratory Support Mechanical ventilation