什么是生物材料? 根据本课程的教材，目前较为合适的定义为：“用于医用器械、与生物体相互作用的无 生命性材料。”*

A. Symbolism of organ synthesis. B. The central question of organ synthesis. C. What is required to synthesize an organ? D. Trans-organ rules of synthesis

B. Conjunctiva synthesis in vivo (regeneration) 1. Structure and function of conjunctiva. 2. Clinical effects of conjunctival scarring. 3. Anatomically well-defined defect. 4. Synthesis of conjunctival stroma, followed by re-epithelialization

Methodology of Organ Synthesis A Skin B Conjunctiva C. Peripheral nerves D. simplest synthetic pathways

TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold Bone

ELEMENTS FOR TISSUE REGENERATIONENGINEERING CELLS Autologous, Adult (pulp and bone marrow stromal stem cell)

TISSUES COMPRISING JOINTS Permanent Regeneration Prosthesis Scaffold

Outline 1. Irreversible injury 2. Regenerative and nonregenerative tissues 3. Antagonistic relation between contraction and regeneration 4. Present theory: Selective inhibition of contraction necessary but not sufficient for regeneration 5. Mechanism

JOINT REPLACEMENT PROSTHESES Fit -Anatomy Function -Kinematics; Range of Motion Fixation Bone cement, bone interdigitation with an irregular surface, bone ingrowth into a porous coating Tribology

BIOMATERIALS-TISSUE INTERACTIONS BIOMATERIAL TISSUE Strength ize scale IOnm 100nm lum 10 um 100 um Imm Modulus of Elasticity Fracture mechanics