上海交通大学教授李大伟电邮daweili(@sjtu.edu.cn 电话：34204744 助教陈昊 电话：34205436 上海交通大学通识核心课 Genes and Human 基因是生命延续的必然选择 Gene Is The Choice of Lives >人类的历史是人类基因扩张的历史
2022-3-11 1 1 Genes and Human 上海交通大学通识核心课 上海交通大学教授 李大伟 电邮 daweili@sjtu.edu.cn 电话：34204744 助教 陈 昊 电话：34205436 基因是生命延续的必然选择 Gene Is The Choice of Lives Ø人类的历史是人类基因扩张的历史
5.Genes and Human Evolution 第五章：人类进化基因选择 1.Human Genes:Mutation Drive Human History 人类基因：基因突变推动人类历史 2.Modern Human( (Homo Sapiens) v.s.The Last Neanderthal 现代人和最后一个尼安德特人 3.Genes and Collaboration: Power and Knowledge Beyond Death 基因与合作：超越死亡的力量扩展与知识积累 2022-3-11
2022-3-11 1 2 5. Genes and Human Evolution 第五章 ：人类进化-基因选择 1. Human Genes: Mutation Drive Human History 人类基因：基因突变推动人类历史 2. Modern Human (Homo Sapiens) v.s. The Last Neanderthal 现代人和最后一个尼安德特人 3. Genes and Collaboration: Power and Knowledge Beyond Death 基因与合作：超越死亡的力量扩展与知识积累
讨论题：什么特征使得一些狼更容易驯化？ Discussion:What make some wolves more likely to be domesticated than others? 相关科学研究进展： Human knowledge advances through scientific research Single-gene model Polygenic model Science DAAAS Science Domestication 29 August 2014: Perspective:Evolution On the origin of Peter Rabbit Kirk E.Lohmueller many genetic variants across the genome have been affected by natural selection throughout domestication.Further,these variants tend to be in regulatory regions located in genes related to brain development 2022-3-11 3
2022-3-11 1 3 讨论题：什么特征使得一些狼更容易驯化？ Discussion: What make some wolves more likely to be domesticated than others? 相关科学研究进展： Human knowledge advances through scientific research Science 29 August 2014: Perspective: Evolution On the origin of Peter Rabbit Kirk E. Lohmueller many genetic variants across the genome have been affected by natural selection throughout domestication. Further, these variants tend to be in regulatory regions located in genes related to brain development
Fig.1 Experimental design and population data.(A)Images of the six rabbit breeds included in the study(sized to reflect differences in body weight)and of a wild rabbit. Dutch French lop A Wild Belgian hare rabbit Champagne d'argent Flemish giant New Zealand white B Time C Belgian hare Champagne d'argent Dutch 1,800.000 Flemish giant 18.,000 French lop New Zealand white FRW1 1400 FRW2 FRW3 IW1 200 IW2 IW3 IW4 IW5 w6 W7 Iw8 IW9 W10 W11 0.010.0080.0060.0040.002 0 Nucleotide diversity M Carneiro et al.Science 2014:345:1074-1079 Science DTAAAS Published by AAAS
Fig. 1 Experimental design and population data.(A) Images of the six rabbit breeds included in the study (sized to reflect differences in body weight) and of a wild rabbit. M Carneiro et al. Science 2014;345:1074-1079 Published by AAAS
Fig.2 Selective sweep and A allele frequency analyses.(A)Plot of FST values between wild and domestic rabbits. A 0.7 0.6 0.5 0.4 0.3 联 0.2 0.1 10 11 12 13 15 16 18192021× Unassigned scaffolds Chromosome B Heterozygosity 0.4 Heterozygosity 0 0.5 05 M H△AP A△AP 1.00 1.00 0.75 UULL hnLL小M鱼 LMl 0,75 叠，L FAT-Hat FT-Het Sweepfinder Sw GRIK2 CCDC 9FXRT S0X2-0T* 215 22757 NAJC19 Chr12 89 0 81 92 93 Mb Chr14 75 76 78 79 Mb D E 7.000.000 0.4 11.0 29 mammals constraint-no gene overlap ▣△AF>=0.8 6,000.000 UTRCoding-Intron 0.8 ▣△AF<O.8 5,000.000 0.6 0.3 4,000.000 坐 气 0.4 3.000.000 0.2 2.000.000 0.2 0.1 1.000,000 0.0 0 -0.2 0-21900 000-00 020100 030-020 880-30 330-030 060-80 望 国 层 曼 是 笔 A allele frequency bins Location relative to nearest TSS Published by AAAS M Carneiro et al.Science 2014:345:1074-1079
Fig. 2 Selective sweep and Δ allele frequency analyses.(A) Plot of FST values between wild and domestic rabbits. Published by AAAS M Carneiro et al. Science 2014;345:1074-1079