Physiological properties of gastrointestinal smooth muscle 消化道平滑肌的特性 General properties(一般特性) o Low excitability o High distensibility(扩张性) o Tonic contraction o Autorhythmicity o High sensitivity to temperature, stretch and chemical stimulation
Physiological properties of gastrointestinal smooth muscle 消化道平滑肌的特性 ◼ General properties (一般特性) Low excitability High distensibility (扩张性) Tonic contraction Autorhythmicity High sensitivity to temperature, stretch and chemical stimulation
Electrophysiological properties(电生理 特性) o Resting membrane potential 50~-60mV lonic basis o Em(selective membrane permeability to K+, Nat Cl and Cazt) o Electrogenic Na*-K* pump
◼ Electrophysiological properties (电生理 特性) Resting membrane potential ◼ −50 ~ − 60 mV ◼ Ionic basis Em (selective membrane permeability to K+ , Na+ , Cl− and Ca2+) Electrogenic Na+ -K+ pump
Slow wave(慢波电位)/ Basic electrical rhythm(BER,基本电节律) The spontaneous rhythmic, subthreshold depolarizations of the cell membrane(slow wave)of the gastrointestinal tract Initiated in the interstitial cells of Cajal (ICC) (pace maker cell
Slow wave (慢波电位) / Basic electrical rhythm (BER, 基本电节律) ◼ The spontaneous rhythmic, subthreshold depolarizations of the cell membrane (slow wave) of the gastrointestinal tract ◼ Initiated in the interstitial cells of Cajal (ICC) (pace maker cell)
Santiago Ramon Y Cajal He and camillo golg received the nobel prize 李确 in 1906 for introduction of the silver-chromate (铬酸银) stain x
Santiago Ramon Y Cajal ◼ He and Camillo Golgi received the Nobel Prize in 1906 for introduction of the silver-chromate （铬酸银）stain
Slow wave/ Basic electrical rhythm ( BER) o Intensity: 10-15 mV o Frequency: 3-12 cpm o lonic mechanism spontaneous rhythmic changes in Nat-Kl pump activity
◼ Slow wave / Basic electrical rhythm (BER) Intensity: 10~15 mV Frequency: 3~12 cpm Ionic mechanism ◼ spontaneous rhythmic changes in Na+ -K+ pump activity