Progressive methods of global multiple sequence alignment Progressive alignment methods use the dynamic programming method to build a msa starting with the most related sequences and d then progressively adding less-related sequences or groups of sequences to the initial alignment (Waterman and Perlwit: 1984; Feng and Doolittle 1987, 1996 Thompson et al. 1994a: Higgins et al. 1996) Relationships among the sequences are modeled by an evolutionary tree in which the outer branches or leaves are the sequences
Progressive methods of global multiple sequence alignment • Progressive alignment methods use the dynamic programming method to build a msa starting with the most related sequences and then progressively adding less-related sequences or groups of sequences to the initial alignment (Waterman and Perlwitz 1984; Feng and Doolittle 1987, 1996; Thompson et al. 1994a; Higgins et al. 1996). • Relationships among the sequences are modeled by an evolutionary tree in which the outer branches or leaves are the sequences
The tree is based on pair-wise comparisons of the sequences using one of the phylogenetic methods Global multiple sequence alignment The methods are used by clustalw and the genetics Computer Group program PILEUP
• The tree is based on pair-wise comparisons of the sequences using one of the phylogenetic methods • Global multiple sequence alignment • The methods are used by CLUSTALW and the Genetics Computer Group program PILEUP
The Progressive Multiple Alignment CLUSTALW Algorithm (Clustal w) Clustal has been around for more than 20 years, and the authors have done much to support and improve the program(higgins and Sharp 1988: Thompson et al. 1994a; Higgins et al. 1996) CLUSTALW is a recent version of CLUSTAL with the w standing for"weighting, to represent the ability of the program to provide weights to the sequence and program parameters, and CLUSTALX provides a graphic interface
CLUSTALW • CLUSTAL has been around for more than 20 years, and the authors have done much to support and improve the program (Higgins and Sharp 1988; Thompson et al. 1994a; Higgins et al. 1996). CLUSTALW is a recent version of CLUSTAL with the W standing for “weighting” to represent the ability of the program to provide weights to the sequence and program parameters, and CLUSTALX provides a graphic interface
HBH Alignment progran HAHU m HOHO HBH 211 HAHU HAHo329197 HBHO 207390204 programmin HAHU MYWHP109810397 HAHO PILHB 9386968470 LGHT 717375747343 二二二二 New Gap HBH Cluster analysis HBO Dynamic HAHU LGHB Programming 〓HAHo PILHB HBH MYWHP HBO n HAHO New Gap HAHU HBH HAHO HBO HAHU HBHU Programming HAHO Increasing Similarity HBHO MYWHP New Gap Baxrenavis and oullette. 200/
Baxenavis and Oullette, 2001
渐进多序列联配算法提出者 罗素·杜立特( Russell f. Doolittle(1931-)
罗素·杜立特（Russell F. Doolittle）（1931-） 渐进多序列联配算法提出者