Tron-Deficiency Anemia Zhongshan Hospital, Fudan University Zou shanhua
Iron-Deficiency Anemia Zhongshan Hospital ,Fudan University Zou Shanhua
Definition Absent iron-store hemoglobin synthesi↓ A microcytic and hypochromic anemia The most common nutritional anemia
Definition Absent iron-store hemoglobin synthesis↓ A microcytic and hypochromic anemia The most common nutritional anemia
cometabolism ron source and absorption 1. Heme iron: hemoglobin stomach acid, prolease heme heme oxygenase protoporphyrin Iron Its absorption is not influenced by food ingrediant
Iron metabolism : Iron source and absorption 1.Heme iron： hemoglobin stomach acid,prolease heme heme oxygenase protoporphyrin iron Its absorption is not influenced by food ingrediant
ron source and absorption 2. Nonheme iron Fe3+→ stomach acid,itC→Fe2+ 3. Contains: 10-15mg/d: 10%o absorbed 4. Absorption portions: duodenum and upper part of unum 5. Absorption rate
Iron source and absorption 2.Nonheme iron： Fe3＋→stomach acid，VitC →Fe2+ 3.Contains:10-15mg/d;10% absorbed 4.Absorption portions：duodenum and upper part of jejunum 5. Absorption rate
ron transportation F Fe ferritin Fest-transferrin-receptor(erythroblast) o mitochondria protoporphyrin, heme ferritin Total iron-binding capacity(TIBC) Serum iron(si) Transferrin saturation SITIBC X100%=33%0 35%o Tansferrin receptor
Iron transportation Fe2+ → Fe3+ → ferritin Fe3+→transferrin→receptor (erythroblast) → mitochondria protoporphyrin heme ferritin Total iron-binding capacity(TIBC) Serum iron (SI) Transferrin saturation :SI/TIBC×100%＝33%~35% Tansferrin receptor