Drug resistance of Gonococcus It's reported continuously that PPNG and non-PPNG resistance strains and spectinomycin norfloxacin and ofloxacin resistance strains have been found in China in recent year. Most of Gonococcus strains popular in China are sensitive to Ceftriazone Mechanism of Drug resistance Gonococcus create PPNG which can split Beta-Lactam cycle of penicillin through plasmid, that can cause it lose antibioticeffect Drug resistance strains caused by chromatosome mutationcan change permeability of bacteria cell wall which cause the resistance to penicillin increase to 2-4 times The mechanisms above have cooperation action
Drug resistance of Gonococcus It’s reported continuously that PPNG and non-PPNG resistance strains and spectinomycin、norfloxacin and ofloxacin resistance strains have been found in China in recent year.Most of Gonococcus strains popular in China are sensitive to Ceftriazone. Mechanism of Drug resistance • Gonococcus create PPNG which can split Beta-Lactam cycle of penicillin through plasmid, that can cause it lose antibiotic effect. • Drug resistance strains caused by chromatosome mutationcan change permeability of bacteria cell wall which cause the resistance to penicillin increase to 2-4 times • The Mechanisms above have cooperation action
Epidemiology Humans are the only natural hosts of Gonococcus and the patients are the only sources of infection Transmission of adult gonorrhea is almost entirely b sexual contact,and transmission through nonsexual contact is extremely rare Epidemic tendency Cases of gonorrhea in developed countries have been unchangeable or decreased, but increased year by year in many developing countries Gonorrhea are the first place of all STDs in our country
Epidemiology Humans are the only natural hosts of Gonococcus, and the patients are the only sources of infection. Transmission of adult gonorrhea is almost entirely by sexual contact,and transmission through nonsexual contact is extremely rare. Epidemic tendency： Cases of gonorrhea in developed countries have been unchangeable or decreased, but increased year by year in many developing countries. Gonorrhea are the first place of all STDs in our country
Clinical menifestation Gonorrhea can be divided into three types Simple gonorrhea(gonorrhea without complications Complicated gonorrhea(gonorrhea with complications) Disseminated gonorrhea
Clinical menifestation Gonorrhea can be divided into three types: – Simple gonorrhea (gonorrhea without complications) – Complicated gonorrhea (gonorrhea with complications) – Disseminated gonorrhea
Simple gonorrhea Single infection of genitourinary tract or other local mucous membrane, including Gonococcal urethritis Gonococcal cervicitis Gonococcal conjunctivitis Gonococcal pharyngitis Gonococcal Proctitis Child gonorrhea
Simple Gonorrhea Single infection of genitourinary tract or other local mucous membrane, including: – Gonococcal urethritis – Gonococcal cervicitis – Gonococcal conjunctivitis – Gonococcal pharyngitis – Gonococcal Proctitis – Child gonorrhea
Gonorrheal urethritis Outbreak is often during 2 to 10 days (averagely 3 to 5 days)after an unprotected sexual intercourse Redness and swelling at urethralorifice with wild stimulation can be presented, followed by yellow mucus or purulent discharge from urethra with frequent micturition, urgent micturition and urodynia The symptoms can be aggravated within the first 2 weeks but then alleviated In untreated cases, the infection can be spread to posterior urethra and later into blood, thus complications or systemic symptoms will manifest
Gonorrheal urethiritis Outbreak is often during 2 to 10 days (averagely 3 to 5 days) after an unprotected sexual intercourse Redness and swelling at urethral orifice with wild stimulation can be presented, followed by yellow mucus or purulent discharge from urethra with frequent micturition, urgent micturitionand urodynia. The symptoms can be aggravated within the first 2 weeks but then alleviated. In untreated cases, the infection can be spread to posterior urethra and later into blood, thus complications or systemic symptoms will manifest