Sleep Stage REM REM REM REM Awake 2 3 4 1 2 3 4 5 6 7 8 Hour 睡眠阶段
Shanghai Jiao Tong University 睡眠阶段
h 上商充通大￥ Shanghai Jiao Tong University Awake ------Stage 1 5ugStage2 小sae Stage 4 mr一 TIME (hours)
Shanghai Jiao Tong University
上游充通大￥ Shanghai Jiao Tong University Sedative-hypnotics >benzodiazepines(苯二氮卓类) widely used clinically now barbiturates (巴比妥类) classical drugs > other newly used drugs
Shanghai Jiao Tong University Ø benzodiazepines （苯二氮卓类） widely used clinically now Ø barbiturates （巴比妥类） classical drugs Ø other newly used drugs Sedative-hypnotics
上 准 S R2 N 1 2 B 3 C- R7 benzodiazepine
Shanghai Jiao Tong University Benzodiazepines benzodiazepine
上游充通大￥ Sedative-hypnotics 后 Shanghai Jiao Tong University Early 1960's Hoffmann-La Roche Sternbach,et al.chlordiazepoxide (Librium利眠宁) N-Me
Shanghai Jiao Tong University Early 1960’s Hoffmann-La Roche Sternbach, et al. chlordiazepoxide （Librium 利眠宁） Sedative-hypnotics