Na+ channelsCheng Long, chenglong_scnu@qq.comSchool of Life Sciences, South China Normal UniversityMar. 13, 20121933华南轩花大学UNIVERSITYSOUTHCHINNORMN
Cheng Long, chenglong_scnu@qq.com School of Life Sciences, South China Normal University Mar. 13, 2012 Na + channels
What'syourassociationwithNat channels?Atargetforspecific,clinicallyimportant,localanaestheticeffectsinneuronsWidespreaduse oflocal anaestheticsforwelloveracentury
What’s your association with Na+ channels? A target for specific, clinically important, local anaesthetic effects in neurons Widespread use of local anaesthetics for well over a century
The outline...RequiredReadings:Marban E,YamagishiT,Tomaselli GF.(1998) Structureandfunctionofvoltage-gatedsodiumchannels.JPhysiol.508(3):647-57GoldinAl.(2o03)Mechanismsofsodiumchannelinactivation.CurrentOpinioninNeurobiology2003,13(3):284-290ScheuerT(2011)Regulationofsodiumchannel activitybyphosphorylation.Seminars in Cell &Developmental Biology22(2):160-165.http://www.sciencedirect.com/science/article/pil/S1084952110001643RuanY,LiuN,PrioriSG.(2oo9)Sodiumchannelmutationsandarrhythmias.Nat Rev Cardiol.6:337-348.FurtherReadings:Dib-HajSD,CumminsTR,BlackJA,WaxmanSG.(2010)Sodiumchannels innormal and pathological pain.Annu RevNeurosci33:325-247Dib-HajSD,BinshtokAM,CumminsTR,JarvisMF,SamadT,Zimmermann K.(2009)Voltage-gated sodium channels in painstates:rolein pathophysiology and targetsfortreatmentBrainResRev.60:65-83
The outline. Required Readings: Marban E, Yamagishi T, Tomaselli GF. (1998) Structure and function of voltage-gated sodium channels. J Physiol. 508(3): 647-57. Goldin Al. (2003) Mechanisms of sodium channel inactivation. Current Opinion in Neurobiology 2003, 13(3): 284–290. Scheuer T (2011) Regulation of sodium channel activity by phosphorylation. Seminars in Cell & Developmental Biology. 22(2): 160-165. http://www.sciencedirect.com/science/article/pii/S1084952110001643 Ruan Y, Liu N, Priori SG. (2009) Sodium channel mutations and arrhythmias. Nat Rev Cardiol. 6: 337-348. Further Readings: Dib-Hajj SD, Cummins TR, Black JA, Waxman SG. (2010) Sodium channels in normal and pathological pain. Annu Rev Neurosci. 33: 325-247. Dib-Hajj SD, Binshtok AM, Cummins TR, Jarvis MF, Samad T, Zimmermann K. (2009) Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment. Brain Res Rev. 60: 65-83
The outline...Thisclasswill cover:TypesandstructureofNatchannelsBiochemical,molecularand genetic propertiesPhysiological rolesand regulationPharmacological significance and disorders
The outline. This class will cover: Types and structure of Na + channels Biochemical, molecular and genetic properties Physiological roles and regulation Pharmacological significance and disorders
IntroductionSodium channelsare responsibleforactionpotentialinitiation andpropagation in excitable cells, including nerve, muscle,andneuroendocrinecelltypesThey are also expressed at low levels in nonexcitable cells, wheretheirphysiological roleisunclear.Sodiumchannelsarethefoundingmembers oftheionchannelsuperfamilyintermsoftheirdiscoveryasaproteinanddeterminationoftheiraminoacidsequence
Introduction Sodium channels are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in nonexcitable cells, where their physiological role is unclear. Sodium channels are the founding members of the ion channel superfamily in terms of their discovery as a protein and determination of their amino acid sequence