(1)Production and scavenging of OFR I)Origin of o.2 ①Mt NAtural oxidation of some substances ENzyme catalysis ④ Toxin acting on cell
(1)Production and scavenging of OFR 1) Origin of O·- 2 ： ①Mt ②Natural oxidation of some substances ③Enzyme catalysis ④Toxin acting on cell
2) Production process of OFR O+e SOD O2+2e+2H Cyta aa2 O2+3e+3H HO●+H2O HOonse O2+4e+4H+ 2HO Single electron reduction ofo
2）Production process of OFR Single electron reduction O2 + e O2 • O2+ 2e + 2H+ H2O2 H2O2 O2 + 3 e + 3H+ HO• + H2O O2 + 4 e + 4H+ 2 H2O Cytaa3 SOD nse Single electron reduction of O2
Haber - Weiss reaction (without Fe+2 02°+副202 02+0+0H SLOW
Haber-Weiss reaction (without Fe+2 ) O2 －• + H2O2 O2 + OH +OH• SLOW
Fenton type of Haber-Weiss reaction ( with Fe +3) +2 02·+副202 H Fast What significance??
Fenton type of Haber-Weiss reaction ( with Fe +3 ) O2 － + H2O2 O2 + OH +OH• Fast • Fe+2 What significance ？？？
3) Scavenging of oFr Water-soluble (1 Low molecule scavenger ②2 Enzymatic scavenger Lipid up soluble
3）Scavenging of OFR ① Low molecule scavenger ② Enzymatic scavenger Water-soluble Lipid-soluble