Chapter 1l Ischemia reperfusion injury Zhao mingyao BMC.ZZU
Chapter 11 Ischemiareperfusion injury Zhao Mingyao BMC.ZZU
Brief history Simple phenomenon 1955, Sewell ligated coronary artery of dog restore blood flow after deligation What ha appened
• 1955, Sewell ligated coronary artery of dog, restore blood flow after deligation. • What happened ? Brief history Simple phenomenon
Clinical Shock. dic Bypass surgery Fibrinolytic therapy Cardiopulmonary operation Organ transplantation Coronary Bypass surgery
Clinical： • Shock , DIC • Bypass surgery • Fibrinolytic therapy • Cardiopulmonary operation • Organ transplantation
Concept of Ischemia-Reperfusion Injury The restoration of blood flow after transient ischemia may induce further reversible or irreversible cellular injury
Concept of Ischemia-Reperfusion Injury The restoration of blood flow after transient ischemia may induce further reversible or irreversible cellular injury
Features of iri 1. reversible> irreversible 2. Massive in organs 3. participating factors oxygen paradox calcium paradOX pH paradox
Features of IRI： 1. reversible → irreversible 2. Massive in organs 3.participating factors oxygen paradox calcium paradox pH paradox