Perfusion fluid Perfusion fluid effect Normal o2 2 paradox Without O2 supply Ca 2+ paradox Without with Deteriorate Injury Ca2t Ca2+ Correcting pH paradox Acidosis acidosis
Without O2 Normal O2 supply Without Ca2+ with Ca2+ Deteriorate injury Acidosis Correcting acidosis effect Perfusion fluid Perfusion fluid pH paradox Ca2+ paradox O2 paradox
Section 1 Etiology of IRI 1. Duration of ischemia 2. Dependency on O2 supply 3. The condition of reperfusion reperfusion pressure, speed, T, Na, Cal, K-t Mg2+
Section 1 Etiology of IRI 1. Duration of ischemia 2. Dependency on O2 supply 3. The condition of reperfusion: reperfusion pressure, speed, T, Na+ , Ca2+, K+ , Mg2+
Effect of Ischemic time on perfusion arrhythmia of rat 100 90 80 70 60 incidence rate 50 □RVA 40 ■RVT 30 口RVF 20 00 5min 10min 30min Ischemic time (min)
Effect of Ischemic time on perfusion arrhythmia of rat 0 1 0 2 0 3 0 4 0 5 0 6 0 7 0 8 0 9 0 100 发生率（%） 5min 10min 30min 缺血时间（min) RVA RVT RVF Ischemic time incidence rate
Section 2 mechanism of ri
Section 2 mechanism of IRI
Part 1. Injury of free radicals Radiation Drugs Pollutants Aging Infection Stress xcessive
Part 1. Injury of free radicals