1. Theory of ammonia intoxication Ammonia is wildly believed to play a role in the pathogenesis of he However, a precise role for ammonia in the pathogens of He has yet to be clearly defined
11 1. Theory of ammonia intoxication Ammonia is wildly believed to play a role in the pathogenesis of HE. However, a precise role for ammonia in the pathogens of HE has yet to be clearly defined
Evidences supporting ammonia intoxication (1The ammonia level in blood or CSF of patient with hE was increased by 1-3 fold 2 HE may be induced by eating nitrogen-containing food in patients with liver cirrhosis, and restricting intake may alleviate he 3 Ammonia-lowering treatment was effective in part of patients with he 4 Animal model of HE may created with ammonium chloride 12
12 Evidences supporting ammonia intoxication ①The ammonia level in blood or CSF of patient with HE was increased by 1~3 fold. ② HE may be induced by eating nitrogen-containing food in patients with liver cirrhosis, and restricting intake may alleviate HE. ③ Ammonia-lowering treatment was effective in part of patients with HE. ④ Animal model of HE may created with ammonium chloride
The metabolism of ammonia NH, <100mg/dI adenylate citrulline arginine ATP Enzymes 75 NH3、 ornithine urea 25% a1NH3← urea
13 citrulline The metabolism of ammonia 1 2 urea 25% ATP Enzymes
(1 Causes of increased plasma level of ammonia 1) Decreased urea synthesis and inadequate removal of ammonia 2) Excessive generation of ammonia 14
14 (1) Causes of increased plasma level of ammonia l ) Decreased urea synthesis and inadequate removal of ammonia 2) Excessive generation of ammonia