Anhui Medical University Establishment of the promordial cardiovasular system 2)Intra-embryonic blood vessels The 18-20th days,blood island appears in the mesenchyma of intraembryonic splanchnic mesoderm to form intraembryonic endothelial tube network By the end of 3rd week,intraembryonic and extra- embryonic endothelial tube networks connect to each other to form primitive cardiovascular system Blood circulation begins at the end of 4nd week 7
11 2) Intra-embryonic blood vessels The 18-20th days, blood island appears in the mesenchyma of intraembryonic splanchnic mesoderm to form intraembryonic endothelial tube network By the end of 3rd week, intraembryonic and extraembryonic endothelial tube networks connect to each other to form primitive cardiovascular system Establishment of the promordial cardiovasular system Blood circulation begins at the end of 4nd week Anhui Medical University
Anhui Medical University Formation and variation of blood islands D15,mesenchymal cells D18-20 intraembryonic in the wall of yolk sac mesenchymal cells Blood island Central cells Peripheral cells Primitive blood cells Endothelial cells 亚 亚 Blood cells Endothelial tube Primitive cardiovascular Endothelial tube network system(later of 3rd weeks) 12
12 Blood island Central cells Primitive blood cells Endothelial tube network Primitive cardiovascular system (later of 3rd weeks) Formation and variation of blood islands D15, mesenchymal cells in the wall of yolk sac D18-20 intraembryonic mesenchymal cells Peripheral cells Endothelial cells Blood cells Endothelial tube Anhui Medical University
Anhui Medical University Establishment of the primordial cardiovasular system o Mesenchyme near the endothelial tube differentiate into smooth muscles and CT,form the vascular medial and adventitia,evolve into artery and vein. 13
13 Establishment of the primordial cardiovasular system Mesenchyme near the endothelial tube differentiate into smooth muscles and CT, form the vascular medial and adventitia, evolve into artery and vein. Anhui Medical University
Anhui Medical University 3)Components of the primordial cardiovascular system Primitive cardiovascular system include: -Cardiac tubes Anterior/posterior cardinal vein Primitive heart dorsal aorta Artery aortic arch intersegmental artery -Vein vitelline vein umbilical artery Chorion umbilical vein vitelline artery 14 Model of primitive cardiovascular system(4th weeks)
14 Primitive cardiovascular system include: 3) Components of the primordial cardiovascular system Model of primitive cardiovascular system (4th weeks) - Cardiac tubes - Artery - Vein Anhui Medical University
Anhui Medical University 3)Components of the primordial cardiovascular system Cardiac tube:paired,fuse into a single cardiac tube at the 4th week. Cardiac tube Cardiac tube Primitive heart d20 Early of 4w Later of 4w 15
15 3) Components of the primordial cardiovascular system Cardiac tube: paired, fuse into a single cardiac tube at the 4th week. d20 Early of 4w Later of 4w Cardiac tube Cardiac tube Primitive heart Anhui Medical University