2.2吡咯烷手性辅剂 MOMO OM O OH RCHO NH— R R MOMO MOMO MOMO >97%d R M syn syn Y%o Ph 30 50 82 Ph 60 88 Me2CH Zr 100 85 Et Zr 100 92 MeCH=ch Zr 100 98
2．2吡咯烷手性辅剂 NH MOMO MOMO N MOMO MOMO OM RCHO N MOMO MOMO O R OH O R OH HO Si Re >97%d.e -------------------------------------------------------------------------------------------- R M syn syn Y% -------------------------------------------------------------------------------------------- Ph Li 30 50 82 Ph Zr 60 1 88 Me2 CH Zr 100 <1 85 Et Zr 100 <1 92 MeCH=CH Zr 100 1 98 -------------------------------------------------------------------------------------------
3氨基醇手性辅剂 O OH RHO SiMe TiCl4 91%-97%e.e NMe
2．3氨基醇手性辅剂 O NMe2 OSiMe3 RHO TiCl 4 O NMe2 O R OH 91%-97% e.e