甲状软骨 甲状腺
甲状腺 甲状软骨
1Phh:s:,氵 7 Follicular cells 8 Parafollicular cells 2 Follicle with- : 3 Follicular tells 9 Interlobular 10 Venule Follicle 11 Interfollicular connective tissu 5 Connective 12 Follicle with tissue septa retracted colloid 6 Arteriole 13 Capillaries A General structure: Fibrous capsule protrudes and divides the parenchyma into lobules containing follicles and rich capillaries B. Follicle: Colloid is surrounded by singer layer epithelium 1. Epithelium: Simple squamous (hypoactive), cuboidal or columnar(hyperactive), depending upon the functional status 17
17 A. General structure: Fibrous capsule protrudes and divides the parenchyma into lobules containing follicles and rich capillaries. B. Follicle: Colloid is surrounded by singer layer epithelium. 1. Epithelium: Simple squamous (hypoactive), cuboidal or columnar (hyperactive), depending upon the functional status
12唤 6 24 7 Epithelial cell has rich RER, G, secreting granules, microvilli, phagosomes, LYS, iodide pump, and receptors for thyrotropin(TsH): 18
18 Epithelial cell has rich RER, G, secreting granules, microvilli, phagosomes, LYS, iodide pump, and receptors for thyrotropin (TSH)
2. Colloid: Homogeneous secretion of epithelium Acidophilic and Pas(+) iodinated thyroglobulin in colloid Contains iodated Colloid thyroglobulin 3. Formation of Apical vesicle triodothyronine(T3)& containing lodide tetraiodothyronine(T4) thyroglobulin ○ oxidation a.AA→(RER)→ thyroglobulin, secreting granules)→ colloid Mannose incorporation b.odde→( iodide pump)→ iodide oxidation in cytoplasm Thyroglobulin colloid→ bound to synthesis tyrosine residues of thyroglobulin→ Amino acids lodide iodated thyroglobulin 19
19 2. Colloid: Homogeneous secretion of epithelium. Acidophilic and PAS (+). Contains iodated thyroglobulin . 3. Formation of triiodothyronine (T 3 ) & tetraiodothyronine (T 4 ): a. AA→ (RER)→ thyroglobulin → (G, secreting granules) → colloid. b. Iodide → (iodide pump) → iodide oxidation in cytoplasm → colloid → bound to tyrosine residues of thyroglobulin → iodated thyroglobulin
激素的合 碘化甲状腺球蛋白 成和分泌 分泌小泡 040③1,O碘活化 溶酶体 合成甲状 胶质小泡 腺球蛋白 蛋白质 台威作 溶体隋的, D合成作用 摄取氨基酸摄碘 T3 T4
摄取氨基酸 20 合成甲状 腺球蛋白 分泌小泡 碘化甲状腺球蛋白 碘活化 溶酶体 胶质小泡 Ｔ3 Ｔ4 激素的合 成和分泌 摄碘 I - I 2O