Susceptibility gene Environmental Factors/Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody t self antigens Multiple system involvement vasculitis
Susceptibility gene Environmental Factors Sex hormone Helper T cell activity Hyperactivated B cell Immune complex Self antibody + self antigens Multiple system involvement vasculitis
五. Pathology 1。 vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative C focal segmental lesions d diffuse e membranous f. sclerosing
五. Pathology 1. vasculitis 2. lupus nephritis a. minimal change b. mesangial proliferative c. focal segmental lesions d. diffuse e. membranous f. sclerosing
A\ Clinical menifestations of sle - m-Multiple system involvement
六.Clinical menifestations of SLE -----Multiple system involvement
1. Nonspecific symptom o fever o loss of weight o inertia
1. Nonspecific symptom ● fever ● loss of weight ● inertia
2 Skin and mucosa e skin symptoms in 80% of patients ● specifIc features:40% malar rash discoid rash o nonspecific features 60% ● photosensitivity40% o baldness 40% oral ulcer 60%/ Raynaud's phenomenon
2.Skin and mucosa ● skin symptoms in 80% of patients ● specific features: 40% malar rash discoid rash ● nonspecific features 60% ● photosensitivity 40% ● baldness 40% ● oral ulcer 60% ● Raynaud’s phenomenon