WHO Classification(2001 (4) AML not otherwise categorized AML minima//y di fferentiation AM without maturat ion AML with maturat ion Acute mye/monocytic /eukemia Acute monob/astic and monocytic / eukemia Acute erythroid /eukemia Acute megakaryob/astic / eukemia Acute basophil/ic /eukemia Acute panmyelosis with mye/fibrosis Mye/oid sarcoma (5) Acute /eukemia of ambiguous /ineage 2021/2/23 xie Yi, Hua Shan Hospital
2021/2/23 xie Yi,Hua Shan Hospital 11 WHO classification (2001) (4) AML not otherwise categorized • AML minimally differentiation • AML without maturation • AML with maturation • Acute myelomonocytic leukemia • Acute monoblastic and monocytic leukemia • Acute erythroid leukemia • Acute megakaryoblastic leukemia • Acute basophilic leukemia • Acute panmyelosis with myelofibrosis • Myeloid sarcoma (5) Acute leukemia of ambiguous lineage
WHO classification(2001) 2 chronic myeloid leukemia (1), chronic myeloproliferative disease Chronic myelogenous leukemia Chronic neutrophilic leukemia Chronic eosinophilic leukemia/ hypereosinophilic syndrome (2), myelodysplastic/myeloproliferative disease Chronic myelomonocytic leukemia Atypical chronic myeloid leukemia o Juvenile myelomonocytic/eukemia 2021/2/23 xie Yi, Hua Shan Hospital 12
2021/2/23 xie Yi,Hua Shan Hospital 12 WHO classification (2001) 2, chronic myeloid leukemia (1), chronic myeloproliferative disease • chronic myelogenous leukemia • Chronic neutrophilic leukemia • Chronic eosinophilic leukemia/hypereosinophilic syndrome (2), myelodysplastic/myeloproliferative disease • Chronic myelomonocytic leukemia • Atypical chronic myeloid leukemia • Juvenile myelomonocytic leukemia
WHO classification(2001) 3 B-ce/l neoplasms (1), Precursor B-cell neoplasm Precursor B lymphoblastic leukemia (2), Mature B-cell neoplasm Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLl) ●B-ce∥pro/ mphocytic/ eukemia Hairy cell leukemia ● Burkitt lymphoma leukemia 2021/2/23 xie Yi, Hua Shan Hospital 13
2021/2/23 xie Yi,Hua Shan Hospital 13 WHO classification (2001) 3, B-cell neoplasms (1), Precursor B-cell neoplasm • Precursor B lymphoblastic leukemia (2), Mature B-cell neoplasm • Chronic lymphocytic leukemia/Small lymphocytic lymphoma (CLL/SLL) • B-cell prolymphocytic leukemia • Hairy cell leukemia • Burkitt lymphoma/leukemia
WHO classification(2001) 4 T-cel//and /k-cell neoplasms (1 Precursor 7-cell neoplasm Precursor Lymphoblastic leukemia (2, Mature T-cell and NK-cell neoplasms T-cell prolymphocytic leukemia T-cell large granular lymphocytic leukemia Aggressive /K leukemiallymphoma Adult T-cel// leukemiallymphoma 2021/2/23 xie Yi, Hua Shan Hospital 14
2021/2/23 xie Yi,Hua Shan Hospital 14 WHO classification (2001) 4, T-cell and NK-cell neoplasms (1), Precursor T-cell neoplasm • Precursor T lymphoblastic leukemia (2), Mature T-cell and NK-cell neoplasms • T-cell prolymphocytic leukemia • T-cell large granular lymphocytic leukemia • Aggressive NK leukemia/lymphoma • Adult T-cell leukemia/lymphoma
Epidemiology incidence 3/105,increase with years acute> chronic aMl>all Special distribution Sex man female=2: 1 Age ALL, adolescent 80%<20y: AML, adult CML, 2050 years old; CLL 50N70 years old Area adult T lymphocytic leukemia CML eastern countries CLL western countries 2021/2/23 xie Yi, Hua Shan Hospital 15
2021/2/23 xie Yi,Hua Shan Hospital 15 Epidemiology : incidence 3/105 ， increase with years? acute>chronic , AML>ALL Special distribution: Sex man：female＝2：1 Age ALL, adolescent 80％<20y; AML, adult CML, 20~50 years old; CLL ,50~70 years old Area adult T lymphocytic leukemia CML, eastern countries CLL, western countries