Leukemia(白血病 劫殺( Xie yi Dep Hematology, Huashan Hospital
2021/2/23 xie Yi,Hua Shan Hospital 1 Leukemia (白血病) 谢毅（Xie yi） Dep.Hematology，Huashan Hospital
Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells(造血干细胞) Leukemia is a malignant blood disorder. (not solid tumor) 2021/2/23 xie Yi, Hua Shan Hospital
2021/2/23 xie Yi,Hua Shan Hospital 2 Concept of leukemia Definition It is the results of the tumor proliferation of heamotopoietic stem cells.（造血干细胞） Leukemia is a malignant blood disorder. (not solid tumor)
Hematopoietic stem cell reproduction HSC lymphoid HSC HSC differentiation early progenitor CFU-GEMM myeloid HSc Heamatopoietic Stem cell(Hsc) is the primary cell of Hematopoietic system and immune system 2021/2/23 xie Yi, Hua Shan Hospital 3
2021/2/23 xie Yi,Hua Shan Hospital 3 Heamatopoietic stem cell reproduction HSC lymphoid HSC HSC differentiation early progenitor CFU-GEMM myeloid HSC Heamatopoietic Stem Cell (HSC) is the primary cell of Heamatopoietic system and immune system
曬秘能键思 Multipotent stem cell ◎ Lymphoid stem Cell Myelaid stem Cell (CFU-S) e-T cell erB Cell NK cell BFU-E ⑤◎ CFU-Meg CFU-Eo CFU-GM CFU-E ③ B Lymphocyte Mast cell Eosinophil CD4 CD8 Plasma Cell Monocyte Neutrophil T Lymphocytes B Call Megakaryocyte Macrophage From"Immunology A Synthesis"(Golub and Green, 1991)
Tumor proliferation of Hsc Differentiation of hsc is blocked Leukemia cells are stopped on a differentiation stage of HSC lack of the normal function Proliferation is out of control and apoptosis is inhibited Leukemia cell is cloned and accumulated in a great quantity infiltration and metastasis 2021/2/23 xie Yi, Hua Shan Hospital 5
2021/2/23 xie Yi,Hua Shan Hospital 5 Tumor proliferation of HSC Differentiation of HSC is blocked. Leukemia cells are stopped on a differentiation stage of HSC & lack of the normal function . Proliferation is out of control and apoptosis is inhibited. Leukemia cell is cloned and accumulated in a great quantity. infiltration and metastasis