3.Clinical manifestation Symptoms and signs-dramatic in complete Amenorrhea and Vaginal bleeding The most common symptom,8-12 weeks Vary from spotting to profuse bleeding,irregular Expel bubble material Abdominal pain Excessive uterine enlargement,contraction or ovarian cysts Uterus enlargement and soft Larger than expected for the gestational date, irregular contour,soft
3. Clinical manifestation Symptoms and signs-dramatic in complete ²Amenorrhea and Vaginal bleeding ÖThe most common symptom, 8-12 weeks ÖVary from spotting to profuse bleeding, irregular ÖExpel bubble material ²Abdominal pain ÖExcessive uterine enlargement, contraction or ovarian cysts ²Uterus enlargement and soft ÖLarger than expected for the gestational date, irregular contour, soft
Ovarian theca lutein cysts e Not easily palpate Regress spontaneously several weeks after uterine evacuation,paralleling the decline of hCG level +Rupture,bleeding and infection cause acute abdominal symptoms and indicates surgery Greater likelihood of developing malignant sequelae Hyperemesis gravidarum Severe nausea and vomiting
²Ovarian theca lutein cysts ÖNot easily palpate ÖRegress spontaneously several weeks after uterine evacuation, paralleling the decline of hCG level ÖRupture, bleeding and infection cause acute abdominal symptoms and indicates surgery ÖGreater likelihood of developing malignant sequelae ²Hyperemesis gravidarum ÖSevere nausea and vomiting
Hyperthyroidism Production of thyrotropin by molar tissue,10% Disappear following evacuation of mole,a little need antithyroid therapy Preeclampsia e In the first or early second trimester Large amounts of vasoactive substances are released from necrotic trophoblastic tissue
²Hyperthyroidism ÖProduction of thyrotropin by molar tissue , 10% ÖDisappear following evacuation of mole, a little need antithyroid therapy ²Preeclampsia ÖIn the first or early second trimester ÖLarge amounts of vasoactive substances are released from necrotic trophoblastic tissue
Laboratory findings B-hCG Radioimmunoassay in serum and urine GAbnormal elevated level decline to normal within 14 weeks following evacuation Doppler fetal hear beat:no
Laboratory findings ²β-hCG ÖRadioimmunoassay Öin serum and urine ÖAbnormal elevated level Ödecline to normal within 14 weeks following evacuation ²Doppler fetal hear beat: no
Ultrasound-confirm Reliable,safe,economical,simple Characteristic pattern:multiple echoes formed by the interface between the molar villi and the surrounding tissue,no normal gestational sac or fetus X-ray Transabdominal amniocentesis combined with amniography honeycomb pattern produced by dispersion of radiopaque dye around the vesicles
Ultrasound-confirm ²Reliable, safe, economical, simple ²Characteristic pattern: multiple echoes formed by the interface between the molar villi and the surrounding tissue, no normal gestational sac or fetus X-ray ²Transabdominal amniocentesis combined with amniography ²honeycomb pattern produced by dispersion of radiopaque dye around the vesicles