Gestational Trophoblastic Diseases(GTDs) Dong xiaojing
Gestational Trophoblastic Diseases (GTDs) Dong xiaojing
Introduction Encompass a spectrum of neoplastic disorders that arise from placental trophoblastic tissue after abnormal fertilization The first and only disseminated solid tumors Highly curable by chemotherapy Unique and characteristic tumor marker:hCG Characters: lack of a fetus,trophoblastic cell hyperplasia,edema of villous stroma,loss of normal villous blood vessels
Introduction Encompass a spectrum of neoplastic disorders that arise from placental trophoblastic tissue after abnormal fertilization The first and only disseminated solid tumors Highly curable by chemotherapy Unique and characteristic tumor marker:hCG Characters: ²lack of a fetus, trophoblastic cell hyperplasia, edema of villous stroma, loss of normal villous blood vessels
Classification Benign- hydatidiform mole (HM) GTDs invasive mole (chorioadenoma Gestational destruens) Throphoblastic choriocarcinoma tumor (GTT) placental site trophoblastic tumor (PSTT)
Classification invasive mole (chorioadenoma destruens) choriocarcinoma placental site trophoblastic tumor (PSTT) GTDs Benign- hydatidiform mole (HM) Gestational Throphoblastic tumor (GTT)
Hydatidiform mole Molar pregnancy After pregnancy,syncytiotrophoblastic and cytotrophoblastic cells proliferate,edema of stroma,hydropic villi to form mole(bubble) Abnormal placenta accompanying specific abnormal genetics
Hydatidiform mole Molar pregnancy After pregnancy, syncytiotrophoblastic and cytotrophoblastic cells proliferate, edema of stroma, hydropic villi to form mole(bubble) Abnormal placenta accompanying specific abnormal genetics
Complete chorionic villi are converted into a mass of clear vesicles Size of vesicles are variable in diameter,hang in clusters from thin pedicles,like grape Incomplete Focal change,fetus or at least an amnionic sac Avascular villi swelling
Complete ²chorionic villi are converted into a mass of clear vesicles ²Size of vesicles are variable in diameter, hang in clusters from thin pedicles, like grape Incomplete ²Focal change, fetus or at least an amnionic sac ²Avascular villi swelling