MICROBIOTA PROMOTES 5-HT BIOSYNTHESIS BY ELEVATING TPHI EXPRESSION IN COLONIC ECS ns n s D ★★★★ 2.0 E工.<o E工<O寸 1.0 SPF GF PO P21 P42 PO P21 P42 P42 SPF GF PO P21 P42 PO P42P42 GF+CONV. SPF+ABX VEH GF+CONV. SPF+ABX VEH
MICROBIOTA PROMOTES 5-HT BIOSYNTHESIS BY ELEVATING TPH1 EXPRESSION IN COLONIC ECS
MICROBIOTA PROMOTES 5-HT BIOSYNTHESIS BY ELEVATING TPHI EXPRESSION IN COLONIC ECS oTph→> substrate; tryptophan(色氨酸)↑ product:5-HITP(5-羟基色氨酸)」 o Oral supplementation of 5-HTP=> 5-HTT
MICROBIOTA PROMOTES 5-HT BIOSYNTHESIS BY ELEVATING TPH1 EXPRESSION IN COLONIC ECS Tph↓=> substrate: tryptophan（色氨酸）↑ => product: 5-HTP（5-羟基色氨酸） ↓ Oral supplementation of 5-HTP => 5-HT↑
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS POSTNATALLY INDUCIBLE ns 2.0 SPF GF PO P21 P42 SPFGF PO P21 P42 PO P21P42P42 SPF+ABX VEH SPF+ABX VE D SPF GF P0... 42 P0. 21 P42 P42 SPF GF PO P21 P42 PO P21 P42 P42 GF+CONV PF+ABX VEH
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS POSTNATALLY INDUCIBLE
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS POSTNATALLY INDUCIBLE CgA 5-HT CgA+5-HT SPF GF GF conv
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS POSTNATALLY INDUCIBLE
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS REVERSIBLE ★食★ E 1100 SPF GF PO P21 P42 Po P21 P42 SPFGF PO P21 P42 Po P21 P42 42 GF+CONV. SPF+ABX VEH GF+CONV."SPF+ABX ns c 0 SPF GF P0 P21. 42.P0. 21 P42 P42 SPF GF P0.21 P42 P0. 21 P421 42 GF+CONV PF+ABX EH
MICROBIOTA-MEDIATED ELEVATION OF HOST 5-HT IS REVERSIBLE