Neocortex Cytoarchitecture varies in different areas ·Number and size of cells ·Thickness of layers graphs of Nissl-stained sections through three sensorimotor areas to show differences in cytoarchitectural organization:primary somatos
Neocortex • Cytoarchitecture varies in different areas • Number and size of cells • Thickness of layers
Dendritic spines Surfaces of dendrites covered with spines Increase dendrite surface area for synapses Faulty development of dendrite spines seen in Down's Syndrome Dendrite complexity and spine numbers first increase postnatally and then decrease with old age
Dendritic spines • Surfaces of dendrites covered with spines • Increase dendrite surface area for synapses • Faulty development of dendrite spines seen in Down’s Syndrome • Dendrite complexity and spine numbers first increase postnatally and then decrease with old age
Dendritic spines Spines become more complex postnatally Spine 5 Month 7 Month Newborn 2 Month Fetal Fetal Infant abnormalities occur in some conditions where menta performance is 8 Month Newborn 18 Month diminished Infant Patau's Mongoloid Syndrome +Ch13 21q
Dendritic spines • Spines become more complex postnatally • Spine abnormalities occur in some conditions where mental performance is diminished +Ch13 -21q
Brodmann's cytoarchitectural areas of cerebral cortex 3 1909 52 areas (0.5X) Brodmann's map
Brodmann’s cytoarchitectural areas of cerebral cortex 1909 52 areas