Genetics of Cancer Lecture 34
Genetics of Cancer Lecture 34
Alterations in different kinds of Genes cause Cancer Oncogenes dominant gain-of-function mutations promote cell transformation Tumor suppressor genes recessive,loss-of-function mutations promote cell transformation Mutator genes Usually recessive,loss-of-function mutations that increase spontaneous and environmentally induced mutation rates
Alterations in different kinds of Genes cause Cancer Oncogenes dominant gain-of-function mutations promote cell transformation Tumor suppressor genes recessive, loss-of-function mutations promote cell transformation Mutator genes Usually recessive, loss-of-function mutations that increase spontaneous and environmentally induced mutation rates
Most of the mutations that contribute to cancer occur in somatic cells-but germ line mutations can also contribute egg sperm zygote growth and mitotic differentiation divisions 2 meiotic divisions mitotic divisions endoderm colon gametes (eggs or sperm)
Most of the mutations that contribute to cancer occur in somatic cells – but germ line mutations can also contribute egg sper m zygot e endod e r m col o n g rowth an d di ff e rentiation mitotic di visions mitotic di visions 2 m eiotic di visions gam etes (eggs or spe r m)
Most of the mutations that contribute to cancer occur in somatic cells but germ line mutations can also contribute egg sperm zygote growth and germ line mitotic differentiation divisions 2 meiotic divisions mitotic divisions endoderm colon gametes (eggs or sperm)
Most of the mutations that contribute to cancer occur in somatic cells – but germ line mutations can also contribute egg sper m zygot e endod e r m col o n g rowth an d di ff e rentiation mitotic di visions mitotic di visions 2 m eiotic di visions gam etes (eggs or spe r m) ger m line
Signal Transduction and Growth Regulation Nuclear Cytoplasmic signal proteins transduction proteins Growth Factor Genes
Cytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Signal Transduction and Growth Regulation