Great Targets for Dominant Acting Oncogenes Secreted Growth factors,e.g.EGF, PDGF Specific Receptors for Growth factors e.g.,RET,EGFR Nuclear Cytoplasmic proteins G-proteins, signal Transcription kinases and transduction factors,e.g., their targets proteins Growth MYC,JUN,FOS e.g..RAS,ABL (RB) Factor Genes
Cytoplasmic signal transduction proteins Nuclear proteins Growth Factor Genes Great Targets for Dominant Acting Oncogenes Secreted Growth factors, e.g. EGF, PDGF Specific Receptors for Growth factors e.g., RET, EGFR G-proteins, kinases and their targets e.g., RAS, ABL, (RB) Transcription factors, e.g., MYC, JUN, FOS
Receptor Tyrosine Kinases(RTKs) Extracellular domain Exterior Cytoplasm Transmembrane domain Kinase active Cytoplasmic domain site Figure by MIT OCW
Receptor Tyrosine Kinases (RTKs) Extracellular domain Cytoplasmic domain Exterior Cytoplasm Kinase activ e site Transmembrane domain Figure by MIT OCW
Receptor Tyrosine Kinases (RTKs) Images removed due to copyright reasons
Receptor Tyrosine Kinases (RTKs) Images removed due to copyright reasons
Extracellular Growth factor Engages with and dimerizes specific receptors on cell surface Images removed due to copyright reasons. Please see Figure 1 in Zwick,E.,J.Bange and A.Ullrich. Dimerized Receptor "Receptor Tyrosine Kinases as Targets for Anticancer Drugs." Trends Mol Med.8,no.1 (Jan 2002):17-23. activates cascade of molecular events Machinery for increased cell proliferation is mobilized
Extracellular Growth factor Engages with and dimerizes specific receptors on cell surface Dimerized Receptor activates cascade of molecular events Machinery for increased cell proliferation is mobilized Images removed due to copyright reasons. Please see Figure 1 in Zwick, E., J. Bange and A. Ullrich. Trends Mol Med. 8, no.1 (Jan 2002): 17-23. "Receptor Tyrosine Kinases as Targets for Anticancer Drugs
Receptor Tyrosine Kinases (RTKs) Images removed due to copyright reasons. Kinases Trans- cription Factors
Receptor Tyrosine Kinases (RTKs) Kinases Transcription Factors Images removed due to copyright reasons