EPEC Infection video Type Iv pili: jerky, twitching motility a Type III secretary system 2016/5/5 E. coli-Junqi's Lecture
2016/5/5 E.coli-Junqi's Lecture 11 EPEC Infection Video Type IV pili: jerky, twitching motility Type III secretary system
Epithelial cells AE lesion 0000 Salmonella k Replicating 儿 T3SS WASI Intimin tt● s ●Acin 2016/5/5 E. coli-Junqi's Lecture 12
2016/5/5 E.coli-Junqi's Lecture 12
Provided by Magdalene so, Phd, University of Washington 5.0kV171mmx8.00kSE(M)3/5/2010 5.00um Bacteria caught in the act of infecting a human cell A cluster of Neisseria gonorrhoeae attached to a human epithelial cell. Bacteria are pseudocolored in yellow. All other features are in grey. The bacteria are covered by a network of fibers called Type IV pili. These Type IV pili extend from, and retract into, the body of the bacterium, much like a fishing line. When the fibers retract, they pull with tremendous force on the surface of a human cell, causing changes to the cell surface. Fiber retraction stimulates the formation of microvilli, seen here as thick tubes underneath and adjacent to the bacteria. It also causes the membrane to form "waves". These and other changes to the human cell caused by Type Iv pili are the beginning of the infection process. 2016/5/5 E. coli-Junqi's Lecture 13
2016/5/5 E.coli-Junqi's Lecture 13 Bacteria caught in the act of infecting a human cell A cluster of Neisseria gonorrhoeae attached to a human epithelial cell. Bacteria are pseudocolored in yellow. All other features are in grey. The bacteria are covered by a network of fibers called Type IV pili. These Type IV pili extend from, and retract into, the body of the bacterium, much like a fishing line. When the fibers retract, they pull with tremendous force on the surface of a human cell, causing changes to the cell surface. Fiber retraction stimulates the formation of microvilli, seen here as thick tubes underneath and adjacent to the bacteria. It also causes the membrane to form “waves”. These and other changes to the human cell caused by Type IV pili are the beginning of the infection process. Provided by Magdalene So, PhD, University of Washington
肠侵袭性大肠埃希菌 (EIEC) ■侵袭力:菌毛,侵袭性蛋白(由侵袭性 质粒编码),Ⅲ型分泌系统 ■脓血便 a)shigeTa or other ■里急后重 into tissues by passing d)Bacteria move om cell to cell (e) Pathogen(bacteria) released from 2016/5/5 E. coli-Junqi's Lecture 14
2016/5/5 E.coli-Junqi's Lecture 14 肠侵袭性大肠埃希菌 （EIEC） 侵袭力：菌毛，侵袭性蛋白(由侵袭性 质粒编码), III型分泌系统 脓血便 里急后重
肠出血性大肠埃希菌 (enterohemorrhagic Ecoli, EHEC) O157:H7:人兽共患,牛、鸡、羊、狗、猪等 ■1975年美国首次发现,1982年作出与肠道疾病相 关的结论; 1996年58月在日本引起大流行,历时3个月,涉 及30个都府县,发病人数超过10,000人,住院 432例,10多人死亡; ■近年来在澳大利亚、欧洲、非洲也有发生; 2016/5/5 E. coli-Jungi's Lecture
2016/5/5 E.coli-Junqi's Lecture 15 肠出血性大肠埃希菌 （enterohemorrhagic E.coli, EHEC） O157：H7 :人兽共患，牛、鸡、羊、狗、猪等 1975年美国首次发现，1982年作出与肠道疾病相 关的结论； 1996年5~8月在日本引起大流行，历时3个月， 涉 及30个都府县，发病人数超过10，000人，住院 432例，10多人死亡； 近年来在澳大利亚、欧洲、非洲也有发生；