Acetylcholine ● Nicotinic receptors Nm(muscular-type or n2 ) skeletal muscle Nn(neuron-type, or Ni): autonomic ganglia, CNS o Muscarinic receptors Postganglionic parasympathetic and a few empathetic sites, CNS Receptor subtypes: Mi-5
Acetylcholine ⚫ Nicotinic receptors – Nm (muscular-type or N2 ): skeletal muscle – Nn (neuron-type, or N1 ): autonomic ganglia, CNS ⚫ Muscarinic receptors – Postganglionic parasympathetic and a few sympathetic sites, CNS – Receptor subtypes: M1-5
Catecholamines ● Norepinephrine Postganglionic sympathetic, CNS, adrenal medulla Receptors:c1,x2,阝1 ● Epinephrine Adrenal medulla CNS Receptors:a12a2,β1,β2 ● Dopamine Autonomic ganglia, CNS Receptors: D 1-5)
Catecholamines ⚫ Norepinephrine – Postganglionic sympathetic, CNS, adrenal medulla – Receptors: a1 , a2 , b1 ⚫ Epinephrine – Adrenal medulla, CNS – Receptors: a1 , a2 , b1 , b2 ⚫ Dopamine – Autonomic ganglia, CNS – Receptors: D(1-5), a1 , b1
Location of ANS Receptors a、hnc. Permissio Sympathetic division Most target tissues innervated by the Cell of target tissue sympathetic division have adrenergic ACh Location receptors. When norepinephrine(NE) released of adrenergic binds to adrenergic receptors, some receptors target tissues are stimulated, and Location others are inhibited. For example, of nicotinic NE released smooth muscle cells in blood vessels are stimulated to constrict, and receptors stomach glands are inhibited Preganglionic neuron Postganglionic neuron Sympathetic division Some sympathetic target tissues Location such as sweat glands, have Location of muscarinic muscarinic receptors, which respond of nicotinic receptors to acetylcholine(ACh). Stimulation of receptors sweat glands results in increased sweat production. ACh ACh released released Cell of target tissue Preganglionic neuron Postganglionic neuron Parasympathetic division All parasympathetic target tissues Cell of target tissue have muscarinic receptors. The Location general response to ACh is excitatory, of muscarinic but some target tissues, such as the heart, are inhibited 米 ACh receptors released Location of nicotinic receptors ACh released Preganglionic neuron Postganglionic neuron
Location of ANS Receptors