Chapter 30 General Principles of the Neuron Activities
Chapter 30 General Principles of the Neuron Activities
Contents ● Neurotransmission o Neurotransmitter and Receptor ● Synaptic Plasticity o Properties of the Synaptic Neurotransmission
Contents ⚫ Neurotransmission ⚫ Neurotransmitter and Receptor ⚫ Synaptic Plasticity ⚫ Properties of the Synaptic Neurotransmission
Part I NEUROTRANSMISSION
NEUROTRANSMISSION Part I
I Synapse 1. Chemical synapse( Classical Synapse) Predominates in the vertebrate nervous system 2. Non-synaptic chemical transmission 3. Electrical synapse Via specialized gap junctions Does occur but rare in vertebrate Ns Astrocytes can communicate via gap junctions
I Synapse 1.Chemical synapse (Classical Synapse) – Predominates in the vertebrate nervous system 2.Non-synaptic chemical transmission 3.Electrical synapse – Via specialized gap junctions – Does occur, but rare in vertebrate NS – Astrocytes can communicate via gap junctions
1. Chemical Synapse Terminal bouton is separated from Copyright O The uo.H Companies, c. Permission required for reproduction or display Action A Xon postsynaptic cell by Cactpotentials Action Caz+ otential synaptic cleft Ca2+ Ⅴ esicles fuse with Protein kinase activates. Protein kinase inactive Calmodulin Synaptic (inactive axon membrane and vesicles phosphorylates synapsin Ntreleased b Docking proteins Synaptic cleft exocytosis Fusion and exocytosis Ca Amount of nts Neurotransmitter oo released released depends upon Cas+ frequency of
1. Chemical Synapse • Terminal bouton is separated from postsynaptic cell by synaptic cleft. • Vesicles fuse with axon membrane and NT released by exocytosis. • Amount of NTs released depends upon frequency of AP