HCV is replicates by rNa-dependent rna polymerase 米 HCV virus attachment Internalization Proge ny virus release (+)RNA Golgi (+)RNA RNA ()RNA Translation replication A Processing Inon morphogenesis NS3-5B comple ER Nucleus Hypothetical model of the Hcv viral life cycle
Hypothetical model of the HCV viral life cycle Nucleus NS3-5B complex NS2 (+) RNA (+) RNA (-) RNA Translation Processing RNA replication ER Golgi Progeny virus release HCV virus attachment Internalization Core E2 E1 p7 Virion morphogenesis HCV is replicates by RNA-dependent RNA polymerase
丙型肝炎:全球性健康问题 HCV Infection: worldwide prevalence <1% 25%49% 5%10% 圆>10% No data available 全球HCv的感染率约为3%,估计约17亿人感染了HCV 我国一般人群抗HCV阳性率为3.2%(1992年) 目前应该是低于该水平:估计约05-1%:1000万)
HCV Infection: Worldwide Prevalence 全球HCV的感染率约为3％，估计约1.7亿人感染了HCV 我国一般人群抗-HCV阳性率为3.2％(1992年） (目前应该是低于该水平: 估计约0.5-1%：1000万） 丙型肝炎：全球性健康问题
Etiology Hepatitis C virus (HCv 10 There are at least 6 major genotypes and more than 50 subtypes(the virus mutates rapidly especially at envelope coding region) 00 One antigen-antibody system HCAg: very low in serum, detectable in liver Anti-HCV: marker for hcv infection 1OHCV RNA: indicator for infectious(active infection) 10 weak resistance, inactivated by 10% chlorid formalin solution (1: 1000)6h heating to60°C10h
Hepatitis C virus (HCV) There are at least 6 major genotypes and more than 50 subtypes (the virus mutates rapidly especially at envelope coding region) One antigen-antibody system HCAg: very low in serum, detectable in liver Anti-HCV: marker for HCV infection HCV RNA: indicator for infectious(active infection) weak resistance, inactivated by 10% chlorid formalin solution(1:1000) 6 h heating to 60oC 10 h Etiology Etiology
Epidemiology There are 170 millions current hcv infected patients in the world Transmission of HCV resembles Hepatitis B, spreading through parenteral route, especially by blood blood products transfusion or IVDU 10 The mode of infection for those patients, who have no risk factors such as transfusion or drug abuse, is uncertain -- family spread is possible but rare (through sharing razors, tooth brushes sexual transmission is believed to be low perinatal spread is also unusual (transmission rate of mother to baby is lower than HBv
Transmission of HCV resembles Hepatitis B, spreading through parenteral route, especially by blood & blood products transfusion or IVDU The mode of infection for those patients, who have no risk factors such as transfusion or drug abuse, is uncertain --- family spread is possible but rare (through sharing razors,tooth brushes … --- sexual transmission is believed to be low --- perinatal spread is also unusual (transmission rate of mother to baby is lower than HBV) Epidemiology Etiology There are 170 millions current HCV infected patients in the world
Etiology Hepatitis D- HDV 无法显示该图片 10 35-37nm spherical particle 0 1.7Kb single-stranded negative RNA folded itself and appears rod-like
Hepatitis D --- HDV 35-37nm spherical particle 1.7Kb single-stranded negative RNA folded itself and appears rod-like Etiology Etiology